CHIMERIC ANTIBIOTICS BASED ON GLYCOPEPTIDES AND 11,12-CYCLIC CARBONATE AZITHROMYCIN AND METHOD FOR PRODUCTION THEREOF Russian patent published in 2015 - IPC C07H17/08 A61K38/14 A61P31/04 

Abstract RU 2570425 C1

FIELD: chemistry.

SUBSTANCE: invention relates to novel compounds used as an antibacterial agent in the pharmaceutical industry, having the formula , where R=

,

and n=1-10. Disclosed are novel effective antibiotics and a method for production thereof via acylation of 11,12-cyclic carbonate of 2'-O-acetyl-4"-O-(ω-aminoalkyl)carbamoyl azithromycin with eremomycin, vancomycin or teicoplanin aglycon in the presence of a condensing agent, followed by removal of the 2'-O-acetyl-protective group.

EFFECT: improved properties.

2 cl, 2 tbl, 2 ex

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RU 2 570 425 C1

Authors

Tevjashova Anna Nikolaevna

Preobrazhenskaja Marija Nikolaevna

Printsevskaja Svetlana Sergeevna

Mirchink Elena Pavlovna

Isakova Elena Borisovna

Zbarskij Viktor Borisovich

Dates

2015-12-10Published

2014-12-22Filed