FIELD: chemistry.
SUBSTANCE: invention relates to novel compounds used as an antibacterial agent in the pharmaceutical industry, having the formula , where R=
,
and n=1-10. Disclosed are novel effective antibiotics and a method for production thereof via acylation of 11,12-cyclic carbonate of 2'-O-acetyl-4"-O-(ω-aminoalkyl)carbamoyl azithromycin with eremomycin, vancomycin or teicoplanin aglycon in the presence of a condensing agent, followed by removal of the 2'-O-acetyl-protective group.
EFFECT: improved properties.
2 cl, 2 tbl, 2 ex
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Authors
Dates
2015-12-10—Published
2014-12-22—Filed