FIELD: organic chemistry, chemical technology, pharmacy.
SUBSTANCE: invention relates to the improved method for preparing (R)-5-(2-benzenesulfonylethyl)-3-N-methylpyrrolidine-2-ylmethyl)-1H-indole of the formula (I):
or its pharmaceutically acceptable salt. Method involves hydrolysis of compound of the formula (II):
that is prepared by catalytic reduction of compound of the formula (III):
. The claimed method excludes formation of dimer in the end product used in medicine.
EFFECT: improved method for preparing.
18 cl, 3 sch, 3 ex
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