FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to (R)-(methylaminosulfonylmethyl)-3-(N-methyl- pyrrolidine-2-ylmethyl)-1H-indole fumarate of the formula (I) 
. The end product is prepared by interaction of compound (I) with fumaric acid. Compound (I) fumarate can be used in pharmaceutical composition for migraine treatment. Compound (I) fumarate is resistant to oxidative decomposition, shows excellent solubility, resistance in the solid state and absence of hygroscopicity. EFFECT: improved method of preparing, valuable physical properties. 5 cl, 3 tbl, 1 dwg
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Year |
Author |
Number |
| ANTIMIGRAINE INDOLE DERIVATIVE SALTS |
1995 |
- Valeri Deniz Kharding
- Ross Dzhejms Makrae
- Ronal'D Dzhejms Ogilvi
|
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| BENZOPYRANES, INTERMEDIATE COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHOD OF TREATMENT |
1994 |
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|
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| CRYSTALLINE POLYMORPHOUS FORM OF (S,S,S)-(N-(1-[2-CARBOXY-3- -N-MESYLLYSYLAMINO)PROPYL]-1-CYCLOPENTYLCARBONYL)TYROSINE, METHODS OF ITS SYNTHESIS, INTERMEDIATE COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHOD OF PATIENT TREATMENT |
1994 |
- Piter Dzhejms Dann
- Majkl Lesli Kh'Juz
|
RU2131869C1 |
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1996 |
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- Sandra Dora Medous
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- Mertiashou Charlz V.
- Grin Stjuart
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|
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| USE OF INDOLE DERIVATIVES AS 5-HTI-AGONISTS |
1994 |
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RU2132683C1 |
| PYRAZOLEPYRIMIDINONES FOR TREATMENT OF IMPOTENTS |
1994 |
- Piter Ehllis
- Nikolas Kennet Terrett
|
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1996 |
- Tomas Frehnsis Dolan
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|
RU2163803C2 |
| DERIVATIVES OF OXA- OR THIADIZOLE, METHODS OF THEIR SYNTHESIS (VARIANTS), PHARMACEUTICAL COMPOSITION |
1997 |
- Aleksandr Roderik Makkenzi
- Ehntoni Vud
- Robert Dzhon Bass
|
RU2162848C2 |
| DERIVATIVES OF (AZETHIDINE-1-YLALKYL)-LACTAMES, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHOD OF TREATMENT OF HUMANS WHEN PATIENTS ARE TREATED BY PRODUCING ANTAGONISTIC EFFECT ON TACHYKININ ACTING IN HUMAN NK-, NK- AND NK-RECEPTORS OR IN THEIR COMBINATION |
1995 |
- Makenzi Aleksandr Roderik
- Marchington Alan Patrik
- Middlton Donal'D Stjuart
- Midouz Sandra Dora
|
RU2150468C1 |
