METHOD FOR PREPARING 3-ALKANOYL- AND 3-ALKYLINDOLES Russian patent published in 2005 - IPC

Abstract RU 2260589 C2

FIELD: organic chemistry, chemical technology.

SUBSTANCE: invention relates to a method for preparing compounds of the formula (I): wherein R means halogen atom; R1 means hydrogen atom (H); R2 means cyano-group (CN); X means oxygen atom (O) or H, H; n = 2, 3, 4, and their acid-additive salts. If X means oxygen atom (O) then the method involves interaction of compound of the formula (II): with compound of the formula (III): R-(CH2)n-CO-L (III) wherein L means halogen atom or others in the process of Friedel-Crafts acylation reaction in the presence of Lewis metalhalides of type R'-Al(Cl)2 as a catalyst wherein R' means (C1-C6)-alkyl. Prepared compound of the formula (I) is isolated as a base or its acid-additive salts followed by reduction by using complex hydrides and activation with Lewis metalhalides of type R'-Al(Cl)2. Method provides preparing compounds with the yield 87-89%.

EFFECT: improved preparing method.

3 cl, 4 ex

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RU 2 260 589 C2

Authors

Bate Andreas

Tilli Gerbert

Dates

2005-09-20Published

1999-12-01Filed