BENZYLPIPERIDINES, METHOD OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF Russian patent published in 2002 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to novel 3-benzylpiperidines of the formula (I): where R¹ means unsubstituted 2- or 3-indolyl, 5H-1,3-dioxolo-[4,5-f]-indolyl or said two compounds are substituted with groups: Hal, CN, AO, COOH or COOA; R² means unsubstituted benzyl- or phenylhydroxymethyl or said two compounds are substituted with groups: A, AO, Hal or CN where Hal means F, Cl, Br or J; A means C₁-C₁₀-alkyl; k = 0 or 1; m = 1, 2, 3 or 4 as racemic or separate steteroisomers and also their physiologically acceptable salts and solvents. Compounds of the formula (I) show effect on the central nervous system and present highly effective ligands of σ-receptors and show strong inhibitory effect with respect to reuptake of 5-HT (serotonin). EFFECT: improved method of synthesis, valuable medicinal properties. 5 cl, 1 tbl, 16 ex