METHOD FOR PREPARING 3-KETO-7α-ALKOXYCARBONYL-SUBTITUTED Δ4,5-STEROID, METHODS FOR PREPARING INTERMEDIATE COMPOUNDS, INTERMEDIATE COMPOUNDS Russian patent published in 2005 - IPC

FIELD: organic chemistry, steroids, chemical technology.

SUBSTANCE: invention describes a method for preparing 3-keto-7α-alkoxycarbonyl-substituted ▵4,5-steroid of the formula (I): wherein is taken among or R³ means hydrogen atom (H), lower alkyl, lower alkoxy-group or cyano-group (CN); R²¹ means hydrogen atom (H) or alkyl; R²⁶ means (C₁-C₄)-alkyl; R⁸ and R⁹ form in common heterocyclic ring system. Method involves interaction of an alkylating agent with 4,5-dihydro-5,7-lactone steroid of the formula (II): wherein R¹⁸ means (C₁-C₄)-alkyl or R¹⁸O-group taken in common form O,O-oxyalkylene bridge or keto-group and R³, R⁸ and R⁹ have above given values in the presence of a base. Compounds of the formula (I) are used as intermediate compounds in improved methods for synthesis of epoxymexerone.

EFFECT: improved preparing method.

56 cl, 42 tbl, 30 sch, 5 dwg, 89 ex