METHOD FOR PREPARING 3-KETO-7α-ALKOXYCARBONYL-SUBTITUTED Δ4,5-STEROID, METHODS FOR PREPARING INTERMEDIATE COMPOUNDS, INTERMEDIATE COMPOUNDS Russian patent published in 2005 - IPC

Abstract RU 2261865 C2

FIELD: organic chemistry, steroids, chemical technology.

SUBSTANCE: invention describes a method for preparing 3-keto-7α-alkoxycarbonyl-substituted ▵4,5-steroid of the formula (I): wherein is taken among or R3 means hydrogen atom (H), lower alkyl, lower alkoxy-group or cyano-group (CN); R21 means hydrogen atom (H) or alkyl; R26 means (C1-C4)-alkyl; R8 and R9 form in common heterocyclic ring system. Method involves interaction of an alkylating agent with 4,5-dihydro-5,7-lactone steroid of the formula (II): wherein R18 means (C1-C4)-alkyl or R18O-group taken in common form O,O-oxyalkylene bridge or keto-group and R3, R8 and R9 have above given values in the presence of a base. Compounds of the formula (I) are used as intermediate compounds in improved methods for synthesis of epoxymexerone.

EFFECT: improved preparing method.

56 cl, 42 tbl, 30 sch, 5 dwg, 89 ex

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RU 2 261 865 C2

Authors

Ng Dzhon S.

Liu Chin

Anderson Dennis K.

Loson Dzhon P.

Vechorek Dzhozef

Kunda Sastri A.

Letendre Leo Dzh.

Pozzo Mark Dzh.

Sing Juehn-Lung L.

Vang Ping T.

Jonan Ehdvard Eh.

Vejer Richard M.

Kovar Tomas R.

Baes Khulio A.

Ehrb Bernkhard

Dates

2005-10-10Published

1997-12-11Filed