FIELD: chemistry.
SUBSTANCE: invention concerns improved methods of obtaining eplerenone pharmaceutical compound: (9α,11α-epoxy-17β-hydroxypregn-4-en-3-one-7α,21-dicarbonic acid, γ-lactone, methyl ether) involving new intermediary products. Methods are implemented by Δ4,6-3-ketosteroid or its ketal transformation into respective Δ4-3-ketosteroid-7α-carbonic acid through a number of stages including oxidation, methylation, epoxydation stages.
EFFECT: reduced process stage number, high yield of product.
11 cl, 38 ex, 15 dwg
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