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2 339 642

(13)

(51)

IPC

C07J1/00(2006-01-01)

C07J21/00(2006-01-01)

(21) (22)

Application

2004128248/04, 2003-03-21

(24)

Start date

2003-03-21

(22)

Actual filing date

2003-03-21

(45)

Published

2008-11-27

(72)

Inventor

Perlman Brjus AllenPadilla Ehmflett GrehgKhejvens Dzheffri L.Makki Sonja S.Vu Khejfeng

(73)

Holder

Farmatsija Ehnd Apdzhon Kompani Lls

METHODS FOR EPLERENONE OBTAINMENT Russian patent published in 2008 - IPC C07J1/00 C07J21/00

Abstract RU 2339642 C9

FIELD: chemistry.

SUBSTANCE: invention concerns improved methods of obtaining eplerenone pharmaceutical compound: (9α,11α-epoxy-17β-hydroxypregn-4-en-3-one-7α,21-dicarbonic acid, γ-lactone, methyl ether) involving new intermediary products. Methods are implemented by Δ^4,6-3-ketosteroid or its ketal transformation into respective Δ⁴-3-ketosteroid-7α-carbonic acid through a number of stages including oxidation, methylation, epoxydation stages.

EFFECT: reduced process stage number, high yield of product.

11 cl, 38 ex, 15 dwg

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RU 2 339 642 C9

Authors

Perlman Brjus Allen

Padilla Ehmflett Grehg

Khejvens Dzheffri L.

Makki Sonja S.

Vu Khejfeng

Dates

2008-11-27—Published

2003-03-21—Filed