FIELD: organic chemistry, neurology, pharmacy.
SUBSTANCE: invention relates to substituted 4-(phenyl-N-alkyl)piperidines of the general formula (1):
wherein R1 represents CF3, -OSO2CF3, -OSO2CH3, -SOR7, -SO2R7, -CN, -CONHR3, F, Cl, Br or J atoms; R2 represents F, Cl, Br, J atoms, -CN, CF3, CH3, -OCH3, hydroxyl (OH) and -NH2; R3 and R4 represent independently hydrogen atom (H); R5 represents (C1-C4)-alkyl, allyl, -CH2CH2OCH3, -CH2CH2CH2F, -CH2CF3, 3,3,3-trifluoropropyl, 4,4,4-trifluorobutyl; R7 represents (C1-C3)-alkyl, CF3, -NH2, -N(CH3)2 and its pharmaceutically acceptable salts. Also, invention discloses pharmaceutical compositions of abovementioned compounds and methods wherein abovementioned compounds are used in treatment of disturbances of the central nervous system.
EFFECT: improved method for treatment, valuable medicinal properties of compounds.
33 cl, 67 ex
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