3-PHENYL-3-METHOXYPYRROLIDINE DERIVATIVES AS MODULATORS OF CORTICAL CATECHOLAMINERGIC NEUROTRANSMISSION Russian patent published in 2014 - IPC C07D207/12 A61P25/00 A61K31/40 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to novel 3-phenyl-3-methoxypyrrolidine derivatives of formula , to any of its enantiomers or any mixture of its enatiomers, or its N-oxides, or its deuterated analogues, or its pharmaceutically acceptable salts, where R¹ stands for F, Cl; R² stands for F, Cl; R³ stands for H, CH₃ or CH₂CH₃; on condition that the said compound does not represent 3-(2,4-difluorophenyl)-3-methoxypyrrolidine and 3-(3,5-difluorophenyl)-3-methoxypyrrolidine.

EFFECT: compounds are useful for a modulation of extracellular levels of dopamine and norepinephrine catecholamines in areas of the mammalian brain cortex, which makes it possible to use them for treatment of the nervous system disorders.

11 cl, 1 tbl, 51 ex