NITROGEN-CONTAINING AROMATIC DERIVATIVES, THEIR USING, MEDICINAL AGENT BASED ON THEREOF AND METHOD FOR TREATMENT Russian patent published in 2005 - IPC

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to new nitrogen-containing aromatic derivatives of the general formula:

wherein A^g represents (1) group of the formula:

; (2) group represented by the formula:

or ; (3) group represented by the formula:

; X^g represents -O-, -S-, C_1-6-alkylene group or -N(R^g3)- (wherein R^g3 represents hydrogen atom); Y^g represents optionally substituted C_6-14-aryl group, optionally substituted 5-14-membered heterocyclic group including at least one heteroatom, such as nitrogen atom or sulfur atom, optionally substituted C_1-8-alkyl group; T^g1 means (1) group represented by the following general formula:

; (2) group represented by the following general formula: . Other radical values are given in cl. 1 of the invention claim. Also, invention relates to a medicinal agent, pharmaceutical composition, angiogenesis inhibitor, method for treatment based on these compounds and to using these compounds. Invention provides preparing new compounds and medicinal agents based on thereof in aims for prophylaxis or treatment of diseases wherein inhibition of angiogenesis is effective.

EFFECT: improved treatment method, valuable medicinal properties of compounds and agents.

40 cl, 51 tbl, 741 ex