FIELD: organic chemistry, medicine.
SUBSTANCE: invention proposes an anti-inflammatory drug representing 3-hydroxy-5-(3-nitrophenyl)-4-(4-chlorobenzoyl)-1-(2-diethylaminoethyl)-3-pyrroline-2-one hydrochloride of the formula (1): 
. This compounds exceeds the standard compound ortophen by specific activity (inhibition of carragheenan edema) as far as it shows anti-inflammatory effect in the dose 1/23 LD50 while ortophen - in the dose 1/7 LD50, and shows low toxicity also.
EFFECT: improved and valuable medicinal properties of compound.
2 tbl, 1 ex
| Title | Year | Author | Number |
|---|---|---|---|
| 1-(3-AMINOPROPYL)-3-HYDROXY-5-(4-FLUOROPHENYL)-4-(4-CHLOROBENZOYL)-3-PYRROLINE-2-ONE HYDROCHLORIDE ELICITING ANTI-INFLAMMATORY ACTIVITY | 2004 |
|
RU2259354C1 |
| 3-(4-NITROBENZOYLMETHYLENE)-1H,4H-HEXAHYDRO-2-QUINOXALONE ELICITING ANTI-INFLAMMATORY ACTIVITY | 2004 |
|
RU2271352C2 |
| 1,4,5,6-TETRAHYDRO-6-OXO-5-(2-PIPERAZINOETHYL)-4-PHENYL-3-(4-CHLOROPHENYL)PYRROLO[3.4-C]PYRAZOLE DIHYDROCHLORIDE ELICITING HYPOTENSIVE AND ANTI-COAGULANT ACTIVITY | 2006 |
|
RU2320661C2 |
| 2-(1,2-DIPHENYL-2-OXOETHYLIDENEHYDRAZINO)-4-(4-METHOXYPHENYL)-4-OXOBUT-2-ENE ACID WITH ANTI-INFLAMMATORY AND ANALGESIC EFFECT | 2006 |
|
RU2348613C2 |
| 4-(4-METHYLPHENYL)-4-OXO-2-[3-(ETHOXYCARBONYL-4,5-R,R-THIOPHEN-2-YLAMINO]BUT-2-ENOIC ACID, HAVING ANTI-INFLAMMATORY AND ANALGESIC ACTIVITY | 2008 |
|
RU2389724C1 |
| 2-((3-CYANO-4,5,6,7-TETRAHYDROBENZO[b]THIOPHEN-2-yl)AMINO)-4-(4-METHOXYPHENYL)-4-OXOBUT-2-ENOIC ACID WITH ANTI-INFLAMMATORY ACTIVITY | 2022 |
|
RU2784434C1 |
| BIS{3-PHENYL-1-[N-(3-PYRIDYL)CARBOXAMIDO]-1,3-PROPANDIONATO} CADMIUM, WHICH HAS ANTI-FLAMMATORY ACTIVITY | 2007 |
|
RU2342364C1 |
| 2-(2-(4-NITROBENZOYL)HYDRAZONO)-4-OXO-4-PHENYLBUTANOIC ACID 4-METHYLBENZYL ETHER WITH ANTI-INFLAMMATORY ACTIVITY | 2022 |
|
RU2798431C1 |
| APPLICATION OF 2-[(3-(AMINOCARBONIL)-4,5,6,7-TETRAHYDROBENZO[b]THIOPHEN-2-yl)AMINO]-4-OXO-4-(4-CHLOROPHENYL)BUT-2-ENOIC ACID IN AS AN ANTI-INFLAMMATORY DRUG | 2022 |
|
RU2785780C1 |
| 4-(4-BROMOPHENYL)-4-OXO-2-{[3-ETHOXYCARBONYL)-4,5-DIMETHYLTHIEN-2-YL]AMINO}-2-BUTENOIC ACID, HAVING ANTI-INFLAMMATORY AND ANALGESIC ACTIVITY | 2012 |
|
RU2485112C1 |
