DERIVATIVES OF 1-AZIRIDINO-1-HYDROXYIMINOMETHYL, METHOD FOR THEIR PREPARING AND MEDICINAL PREPARATIONS COMPRISING THESE COMPOUNDS Russian patent published in 2005 - IPC

FIELD: organic chemistry, chemical technology, medicine, pharmacy.

SUBSTANCE: invention relates to new derivatives of 1-aziridino-1-hydroxyiminomethyl of the general formula (I):

wherein R means a single bond or organic radical that can bind aziridinoxime groups by a covalent bond and taken among the group including saturated or unsaturated alkanes with normal or branched chain and comprising up to 6 carbon atoms, substituted azino-group -(R')C=N-N=C(R'') wherein R' and R'' represent independently of one another hydrogen atom or lower alkyl, heterocyclic compounds comprising from 3 to 6 atoms in ring and up to 4 heteroatoms taken among -N- and -O-, and aromatic compounds comprising up to 8 atoms in ring; R₁ and R₂ mean independently of one another -H, -COOH, -COOCH₃, -COOC₂H₅ or -CONH₂; n means a whole number 2 or 3; with exception the compound wherein R represents a single bond and R₁ and R₂ are both hydrogen atom, and also with exception the compound wherein R represents a single bond and one of substitutes is hydrogen atom among the group R₁ and R₂. Also, invention describes a method for their preparing and medicinal preparations comprising these compounds that possess an antitumor effect.

EFFECT: improved preparing method, valuable medicinal properties of compounds and preparations.

7 cl, 3 tbl, 19 ex