FIELD: chemistry.
SUBSTANCE: invention represents 3-aminosubstituted 6-(3,5-dimethylpyrazol-1-yl)-1,2,4,5-tetrazines, which applied as anti-tuberculosis medications make it possible to increase activity and specificity of antimicrobacterial action, extend its spectrum (impact on atypical strains of mycobacteria) as well as reduce toxicity in comparison with analogues.
EFFECT: toxicity of claimed compounds is 10-20 times lower than toxicity of anti-tuberculosis medications applied in medicine.
5 tbl, 16 ex
| Title | Year | Author | Number |
|---|---|---|---|
| SELECTIVE ANTITUBERCULOSIS AGENT REPRESENTING 3-HYDRAZONO-6-(3,5-DIMETHYLPYRAZOL-1-YL)- 1,2,4,5-TETRAZINE AND METHOD FOR PREPARING IT | 2011 |
|
RU2479311C2 |
| SELECTIVE ANTIBACTERIAL AGENTS, REPRESENTED BY 3-(AZOL-1-YL)-6-AMINO-SUBSTITUTED 1,2,4,5-TETRAZINES | 2017 |
|
RU2642882C1 |
| ANTI-TUBERCULOSIS AGENTS BEING 3,7-DISUBSTITUTED [1,2,4]TRIAZOLO[1,5-b][1,2,4,5]TETRAZINES | 2022 |
|
RU2802300C1 |
| ADAMANTANE-CONTAINING INDOLES AND THEIR HYDROCHLORIDES WITH MICROTUBULES STABILIZING PROPERTY, METHODS OF THEIR PRODUCTION, PHARMACOLOGICAL AGENT BASED THEREON AND METHOD OF TREATING AND PREVENTING DISEASES ASSOCIATED WITH MICROTUBULE SYSTEM DISORDERS | 2015 |
|
RU2608631C1 |
| 6-SUBSTITUTED 3-AZOLYLIMIDAZO[1,2-b][1,2,4,5]TETRAZINES SHOWING ANTICANCER ACTIVITY | 2013 |
|
RU2527258C1 |
| 3-GUANIDINOAZOLO[1,2,4,5]TETRAZINES HAVING ANTIGLYCATING ACTIVITY AND A PROCESS FOR THEIR PREPARATION | 2017 |
|
RU2668971C1 |
| SUBSTITUTED AZOLO[1,2,4,5]TETRAZINES - INHIBITORS OF ANTIBACTERIAL SERINE-THREONINE PROTEIN KINASES | 2011 |
|
RU2462466C1 |
| 4-ISOPROPYL-6-R-IMIDAZO[1,2-B][1,2,4,5]TETRAZIN-3(4H)- ES WITH ANTIBACTERIAL ACTIVITY AGAINST NEISSERIA GONORRHOEAE | 2020 |
|
RU2754554C1 |
| 3-(TRINITROMETHYL-ONN-AZOXY)-4-NITRAMINOFURAZANS AND METHODS FOR PRODUCTION THEREOF | 2012 |
|
RU2485108C1 |
| 3-GUANIDINO-6-R-TRIAZOLO[4,3-B][1,2,4,5]TETRAZINES WITH ANTIBACTERIAL ACTIVITY | 2018 |
|
RU2663890C1 |
