FIELD: organic chemistry, chemical technology.
SUBSTANCE: invention relates to a method for preparing derivatives of 2-(6-substituted-1,2-dioxane-4-yl)-acetic acid of the formula (1) 
or its salt, or acid wherein X means halogen atom, tosylate, mesylate, acyloxy-group, aryloxy- or nitro-substituted benzenesulfonyl group; each R1, R2 and R3 means independently (C1-C3)-alkyl group from compound of the formula (2):
wherein X has abovementioned values by using a suitable acetylation agent in the presence of acidic catalyst and its following conversion, if necessary, to the corresponding salt or acid. These compounds are intermediate substances in synthesis of statins that represent inhibitors of HNG-CoA-reductase. Also, invention relates to new parent compounds of the formula (2) in (4R,6S)-forms and new compounds of the formula (1b) given in the description. Invention provides preparing a valuable intermediate substance with high yield.
EFFECT: improved preparing method.
11 cl, 9 ex
| Title |
Year |
Author |
Number |
| 2,2-DIALKYL OR TRANS-2,2-DIALKYL-3,4-DIHYDRO-3-HYDROXY-6- (PYRIDIN-4-YL)-2H-1-BENZOPYRANS |
1992 |
|
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2000 |
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