FIELD: organic chemistry, chemical technology.
SUBSTANCE: invention relates to a method for preparing derivatives of 2-(6-substituted-1,2-dioxane-4-yl)-acetic acid of the formula (1) 
or its salt, or acid wherein X means halogen atom, tosylate, mesylate, acyloxy-group, aryloxy- or nitro-substituted benzenesulfonyl group; each R1, R2 and R3 means independently (C1-C3)-alkyl group from compound of the formula (2):
wherein X has abovementioned values by using a suitable acetylation agent in the presence of acidic catalyst and its following conversion, if necessary, to the corresponding salt or acid. These compounds are intermediate substances in synthesis of statins that represent inhibitors of HNG-CoA-reductase. Also, invention relates to new parent compounds of the formula (2) in (4R,6S)-forms and new compounds of the formula (1b) given in the description. Invention provides preparing a valuable intermediate substance with high yield.
EFFECT: improved preparing method.
11 cl, 9 ex
| Title |
Year |
Author |
Number |
| 2,2-DIALKYL OR TRANS-2,2-DIALKYL-3,4-DIHYDRO-3-HYDROXY-6- (PYRIDIN-4-YL)-2H-1-BENZOPYRANS |
1992 |
|
RU2104277C1 |
| TERTIARY BUTYL-(E)-(6-{2-[4-(4-FLUOROPHENYL)-6-ISOPROPYL-2-[METHYL(METHYLSULFONYL)AMINO]-PYRIMIDINE-5-YL}-(4R,6S)-2,2-DIMETHYL[1,3]DIOXANE-4-YL]ACETATE AND METHOD FOR ITS PREPARING, DIPHENYL-[4-(4-FLUOROPHENYL)-6-ISOPROPYL-2-[METHYL(METHYLSULFONYL)AMINO]-PYRIMIDINE-5-YLMETHYL]PHOSPHINE OXIDE, METHODS FOR PREPARING (E)-7-[4-(4-FLUOROPHENYL)-6-ISOPROPYL-2-[METHYL(METHYLSULFONYL)AMINO]-PYRIMIDINE-5-YL]-(3R,5S)-3,5-DIHYDROXYHEPT-6-ENOIC ACID AND ITS DERIVATIVES |
2000 |
- Koike Kharuo
- Kabaki Mikio
- Tehjlor Najdzhel Filip
- Dioratsio Lui Dzhozef
|
RU2243969C2 |
| HEXAHYDRONAPHTHALENE ESTER DERIVATIVES, THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF |
1994 |
- Sadao Isikhara
- Khirosi Kogen
- Teiitiro Koga
- Eiiti Kitazava
- Nobufusa Serizava
|
RU2114101C1 |
| STEREOISOMERIC INDOLE COMPOUNDS, METHOD OF THEIR SYNTHESIS AND THEIR USING |
1998 |
- Mori Masao
- Nakagava Masako
- Nisida Atsusi
- Fuva Mikhoko
- Saito Kharuo
- Matsunaga Takajuki
- Takakhasi Satosi
- Khasegava Tika
|
RU2182908C2 |
| PROPHYLACTIC OR THERAPEUTIC AGENT AND PHARMACEUTICAL COMPOSITION COMPRISING HETEROCYCLIC COMPOUND |
2001 |
- Kuvabara Kendzi
- Aoki Tomijosi
|
RU2259361C2 |
| DERIVATIVES OF PYRAZINE OR THEIR SALTS, PHARMACEUTICAL COMPOSITION CONTAINING THESE COMPOUNDS AND INTERMEDIATE COMPOUNDS FOR THEIR PREPARING |
2001 |
- Egava Khirojuki
- Furuta Jousuke
- Sugita Dzun
- Uekhara Sajuri
- Khamamoto Soiti
- Jonezava Kendzi
|
RU2297414C2 |
| NOVEL DIPEPTIDYL PEPTIDASE IV INHIBITORS, SYNTHESIS METHODS THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAID INHIBITORS |
2007 |
- Gopalan Balasubramanian
- Ravi Dkhamdzhevar
- Rashid Mokhammed
- Sridkhara Svami Keshavapura Khosamaneh
- Ishtijak Akhmad
|
RU2443687C2 |
| DERIVATIVES OF AMINOALCOHOLS, PHARMACEUTICAL COMPOSITION, METHOD FOR PROPHYLAXIS OR TREATMENT, INTERMEDIATE COMPOUNDS AND METHOD FOR PREPARING INTERMEDIATE COMPOUNDS |
2001 |
- Nisi Takakhide
- Takemoto Tosijasu
- Simozato Takaiti
- Nara Futosi
|
RU2233839C1 |
| METHOD OF SYNTHESIS OF 2-METHOXYMETHYLPENEMS |
1990 |
- Ehttore Perrone[It]
- Marko Al'Pegani[It]
- Franko Dzarini[It]
- Dzhuzeppe Madzini[It]
- Dzhovanni Francheski[It]
|
RU2049786C1 |
| METHOD FOR PREPARING DIOXANEACETIC ACID ESTERS |
2003 |
- Bakel Van Khermanus Karolus Katerina Karel
- Kallan Dominik Monik Sharl'
- Koojstra Jakob Khermanus Matteus Khero
- Maas Peter Jokhannes Dominikus
|
RU2315761C2 |
