SMALL MOLECULES AS ROTAMASE ENZYME ACTIVITY INHIBITORS Russian patent published in 2006 - IPC C07D207/16 C07D405/06 C07D409/06 C07D417/08 

Abstract RU 2269514 C9

FIELD: biochemistry.

SUBSTANCE: invention relates to new compounds of formula wherein R1 represents linear or branched C1-C9-alkyl optionally substituted with C3-C8-cycloalkyl, C6-cycloalkyl, 2-furil; 3-furil, 2-thiazolyl, 2-thenyl, 3-thienyl, phenyl; X represents oxygen, NR4, wherein R4 is H, C1-C4-alkyl; Z represents H with the proviso, that when X and Y are oxygen, R1 is not methyl, ethyl, isopropyl, isobutyl or phenyl; and when X is oxygen, and Y is NR2, wherein R2 is hydrogen, methyl, isopropyl or tert-butyl R1 is not methyl. Compounds of present invention are useful as synthetic intermediates for bioactive substances.

EFFECT: new synthetic intermediates for bioactive substances.

8 cl, 28 dwg, 3 tbl, 38 ex

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RU 2 269 514 C9

Authors

Khehmilton Gregori S.

Stajner Dzhozef P.

Dates

2006-02-10Published

1996-06-05Filed