1,3-DIOXOLANES AND METHOD FOR PRODUCTION THEREOF Russian patent published in 2006 - IPC C07D317/28 A61K31/495 A61P11/00

Abstract RU 2269522 C2

FIELD: organic chemistry, pharmaceuticals.

SUBSTANCE: invention relates to new 1,3-dioxolane derivatives of formula 1 wherein R_a and R_b are independently hydrogen or C₁-C₆-alkyl; or R_a and R_b together with the carbon atom to which they are attached form optionally substituted 4-7-membered ring. Methods for production of said compounds and optical resolution thereof also are disclosed. Compounds of present invention are useful as synthetic intermediates for (-)-3-(4-phenyl-1-piperasinyl)-1,2-propanediol and salts thereof having antitussive activity.

EFFECT: new 1,3-dioxolane derivatives useful in pharmaceutical production.

8 cl, 8 ex

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RU 2 269 522 C2

Authors

Allegretti Marchello

Chesta Marija Kandida

Kurti Roberto

Nikolini Luka

Dates

2006-02-10—Published

2001-07-18—Filed