DERIVATIVES OF CARBOXYLIC ACIDS WITH OXAZOLE[5,4-d]PYRIMIDINE CYCLE Russian patent published in 2017 - IPC C07D498/04 A61K31/519 

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of formula I or a physiologically acceptable salt thereof, where A denotes -CH₂- or O; X denotes (C₁-C₆)-alkanediiyloxy group, wherein oxygen atom of (C₁-C₆)-alkanediiyloxy group is bonded to Y group; Y denotes phenylene, where in phenylene one or more carbon ring atoms are optionally substituted with identical or different (C₁-C₄)-alkyl; R¹ denotes a hydrogen atom; R² denotes (C₁-C₆)-alkyl; R³ denotes (C₁-C₆)-alkyl, wherein alkyl optionally has one or more substitutes in form of fluorine atoms, or R³ is phenyl, where in phenylene one or more carbon ring atoms are optionally substituted with identical or different halogen. Invention also relates to a pharmaceutical composition for activation of EDG-1 receptor, containing at least one compound of formula I or its physiologically acceptable salt and pharmaceutically acceptable carrier.

EFFECT: technical result is derivatives of carboxylic acids with oxazole[5,4-d] pyrimidine cycle for use as a medicinal agent for EDG-1 receptor activation.

4 cl, 1 tbl, 9 ex