FIELD: natural compounds.
SUBSTANCE: invention relates to a method for isolating betulin representing a pentacyclic triterpenoid of lupan series from the white-stem birch bark. Method involves extraction of birch bark with methyl-tert.-butyl ester, the following treatment of extract with alkali solution and recrystallization of the prepared product from ethyl acetate. The yield of betulin is 15% (as measured for birch bark dry weight) with purity above 95%. Method allows exclusion of labor-consuming and expensive chromatography methods for purifying betulin. Invention can be used in chemistry, medicine and pharmacy.
EFFECT: improved preparing method.
2 cl, 2 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR PREPARING BETULIN AND LUPEOL | 2004 |
|
RU2270202C1 |
| METHOD OF PRODUCING BETULIN | 2013 |
|
RU2524778C1 |
| METHOD OF BETULIN PREPARING | 2001 |
|
RU2184120C1 |
| METHOD OF OBTAINING BETULIN | 2017 |
|
RU2640587C1 |
| METHOD OF ISOLATING BETULINOL | 1998 |
|
RU2138508C1 |
| WAY OF RECEPTION OF BIOLOGICALLY ACTIVE SUBSTANCES FROM BIRCH BARK | 2008 |
|
RU2363486C1 |
| METHOD OF PRODUCING BETULINOL DIACETATE | 2010 |
|
RU2436791C1 |
| METHOD OF ISOLATION OF BETULINOL | 2002 |
|
RU2206572C1 |
| METHOD OF PROCESSING BIRCH BARK TO OBTAIN BETULIN AND SUBERIC ACIDS | 2011 |
|
RU2460741C1 |
| METHOD OF PROCESSING BIRCH BARK TO OBTAIN BETULIN AND SUBERIC ACIDS | 2016 |
|
RU2620814C1 |
