METHOD OF MANUFACTURING POROUS MATERIAL FROM FIBROIN/CHITOSAN MIXTURE Russian patent published in 2006 - IPC C08L5/08 C08L89/00 A61K38/39 A61K47/36 C08J9/00 

FIELD: pharmaceutical industry, dosage form preparation methods.

SUBSTANCE: invention relates to manufacturing articles by way of recovering natural polymers fibroin and chitosan from solutions, which substances can be used as carriers for administering drugs (capsules, fibers, variously shaped artificial substitutes). Fibroin solution dialyzed against lithium bromide aqueous solution is mixed with chitosan solution, whereupon solvent is evaporated and recovered fibroin and chitosan are dried and dissolved in hexafluoroisopropanol at pH 4.5-5.5 and 25-50°C to concentration between 1 and 15 wt % at fibroin-to-chitosan ratio between 9:1 and 1:4. Fibroin is preliminarily dissolved in 6-10 M lithium bromide aqueous solution and, after dialysis, dried at temperature not higher than 40°C. Porous material recovered after evaporation of solvent is treated with methanol for at least 5 min at liquor ratio between 1:1 and 1:20.

EFFECT: improved drug release control due to specified degree of swelling through fibroin/chitosan material pores and increased integrity of material to 70% resulting in several times slowed down degradation of porous material in body.

4 cl, 1 dwg, 2 tbl, 16 ex