METHOD OF FORMATION OF THREE-DIMENSIONAL BIORESORBABLE STRUCTURES Russian patent published in 2019 - IPC A61K38/17 A61K35/646 A61L27/22 

FIELD: medicine.

SUBSTANCE: invention relates to medicine and biotechnology. Method for obtaining bioresorbable three-dimensional porous structures based on methacrylized gelatin and silk fibroin, comprising the following stages: dissolving silk fibroin in an aqueous solution of lithium bromide; freezing of an aqueous solution of silk fibroin and lyophilization; dissolving gelatin in potassium phosphate buffer and adding to the solution an excess of methacrylic anhydride; carrying out the reaction of methacrylization of gelatin; adding to the reaction mixture potassium phosphate buffer, followed by cooling and dialysis; freezing the resulting product and lyophilization; obtaining an aqueous solution of regenerated silk fibroin; obtaining a solution of methacrylated gelatin in DMSO and its cooling; adding a photoinitiator to the methacrylized gelatin solution; introducing a solution of regenerated silk fibroin into a mixture of methacrylized gelatin and a photoinitiator, followed by photopolymerization; treatment with 96 % ethyl alcohol hydrogels obtained after photopolymerization; removal of residual solvents.

EFFECT: invention provides a high photopolymerization rate, as well as the possibility of obtaining porous structures of a given shape and with a controlled structure.

4 cl, 2 ex, 1 dwg