FIELD: pharmaceutical industry.
SUBSTANCE: invention relates to parantheral composition based on oil-covered amphothericin B in form of structured emulsion containing a) oil phase (up to 30 mass/vol %), selected from vegetable oil group such as soy oil, sesame oil, safflower oil; b) amphothericin B (0.05-1 mass/vol %), dispersed in oil phase; c) water of aqueous phase; d) modified agent such as glycerol, mannitol, dextrose, dissolved in aqueous phase; and e) emulsifier, such as natural phosphatides (up to 3 mass/vol %) dispersed in aqueous phase. Composition of present invention allows achievement LD50 not less than 400 mg/kg in one dose administration and not less than 40 mg/kg in repeated administration in mice. Method for production of said composition also is disclosed.
EFFECT: parantheral composition of improved effectiveness.
14 cl, 11 ex, 15 dwg, 20 tbl
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