DERIVATIVES OF MUTILINS AND THEIR USING AS ANTIBACTERIAL AGENTS Russian patent published in 2006 - IPC C07C323/52 C07D211/60 A61K31/445 A61P31/04

Abstract RU 2276135 C2

FIELD: organic chemistry of natural compounds, pharmacy.

SUBSTANCE: invention relates to derivatives of mutilins of the formula (I): wherein R means hydrogen atom or alkyl; R₁ means group of the formula: wherein X means sulfur or oxygen atom, -NR₁₀or -N⁺(R'₁₀)₂; R₉ means amino-group, alkyl, aryl, heterocyclyl or mercapto-group, and if X means oxygen atom then hydrogen atom represents the additional value for R₉; R₂ means phenylene; R₄ means hydrogen atom or alkyl; R₅ means hydrogen atom or alkyl; each among R₃, R'₃, R₇ and R₈ means independently of one another hydrogen or deuterium atom; or R and R₂ in common with nitrogen atom to which they are bound form 5- or 6-membered ring; R₁ means group of the formula: . Also, invention describes pharmaceutical composition based on compounds of the formula (I), method for treatment of diseases caused by microorganisms, and using these compounds as antibacterial agents in medicine and veterinary science.

EFFECT: valuable medicinal and veterinary properties of compounds and pharmaceutical composition.

12 cl, 2 tbl, 52 ex

Similar patents RU2276135C2

Title	Year	Author	Number
METHOD OF PRODUCING PLEUROMUTILINS	2007	Makher Ingol'F Berger Andreas Dekristoforo Martin	RU2512591C2
METHOD OF TREATMENT OR PREVENTION OF PHYSIOLOGICAL AND/OR PATHOPHYSIOLOGICAL CONDITIONS MEDIATED BY GROWTH HORMONE SECRETION STIMULATING RECEPTORS, TRIAZOLE AND BASED PHARMACEUTICAL COMPOSITION	2006	Beglen Dam'En Demanzh Ljuk Martine Zhan Mulen Alin Perrissoud Daniehl' Ferents Zhan-Alen	RU2415134C9
DERIVATIVES OF HETEROARENE CARBOXAMIDE, METHOD FOR THEIR PREPARING, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND USING	2003	Gmajner Peter Khjubner Kharal'D Shlotter Karin	RU2320656C2
7-ACYLAMINOCEPHALOSPORINS SUBSTITUTED IN POSITION 3 WITH CYCLIC AMINOGUANIDINE GROUPS	1999	Asher Gerd Khajl'Majer Verner Ludesher Iogannes Vizer Jozef Shrants Mikhaehl' Khil'Debrandt Iogannes	RU2245884C2
SULFATED AMINO ACID DERIVATIVES AND METALLOPROTEINASE INHIBITORS COMPRISING THEREOF	1997	Vatanabe Fumikhiko Tsuzuki Khiroshige Okhtani Mitsuaki	RU2198656C2
ARYL-S(O)N-SUBSTITUTED CARBOXYLIC-HYDROXAMIC ACIDS AND METHOD OF THEIR SYNTHESIS	1996	Bender Stiven Li Broka Kris Allen Kehmpbell Dzheffri Allen Kastelkhano Arlindo Lukas Khendriks Robert Tehn Sarma Keshab Fisher Lourens Ehmerson	RU2175316C2
COMPOUND WHICH IS PRO-DRUG OF LANOSTEROL, AS WELL AS METHOD FOR PRODUCTION THEREOF AND USE THEREOF	2018	Liu, Yizhi Wang, Yandong Li, Xiaolin Luo, Zhi Shen, Liang Hou, Lijuan Wen, Xinxin He, Haiying Li, Jian Chen, Shuhui	RU2720677C1
METHOD FOR PREPARING COMPOUNDS, COMPOSITION FOR PREPARING MEDICINAL AGENT	2001	Jorgensen Majkl Keller Majkl Miller Ehndr'Ju Dejvid Peruzel' Ehrik	RU2290409C2
CONDENSED TRICYCLIC BENZIMIDAZOLE DERIVATIVES AS MODULATORS OF TNF ACTIVITY	2014	Aleksander Rikki Piter Kalmiano Mark Daniel Defejs Sabine Dyure Veronik Delini Mikhael Kher Yag Paul Dzhekson Viktoriya Elizabet Keje Zhan Kroplin Boris Mak-Koss Malkolm Sabnis Jogesh Anil Selbi Mattyu Dankan Svinnen Dominik Lui Leon Van-Khautvin Natali Chzhu Chzhaonin Vener Folkmar Khajnelt Uve	RU2689777C1
METHOD FOR PREPARING DISCODERMOLID AND ITS ANALOGS AND INTERMEDIATE COMPOUNDS	2001	Frederik Rej Kinder	RU2283309C2

RU 2 276 135 C2

Authors

Asher Gerd

Berner Khajnts

Khil'Debrandt Iogannes

Dates

2006-05-10—Published

2000-07-28—Filed