DERIVATIVES OF HETEROARENE CARBOXAMIDE, METHOD FOR THEIR PREPARING, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND USING Russian patent published in 2008 - IPC C07D409/12 C07D405/12 C07D403/12 C07F17/02 A61K31/496 A61P25/00

Abstract RU 2320656 C2

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to N-[(4-phenyl-1-piperazinyl)alkyl]-substituted heteroarene carboxamide of the general formula (I): and structurally similar 2-ferrocenyl compounds of the general formula (II): showing activity with respect to neuroreceptors and wherein R means hydrogen atom, (C₁-C₆)-alkyl, halogen atom; R₁, R₂ and R₃ are chosen independently from hydrogen atom, hydroxy group, (C₁-C₆)-alkyl, (C₁-C₄)-alkoxy group, halogen atom, trifluoromethyl and cyano group; X can represent sulfur atom (S), oxygen atom (O), -NH or Te. Proposed compounds can be used in treatment of the central nervous system diseases. Also, invention describes methods for synthesis of these compounds, a pharmaceutical composition based on thereof and using for preparing a drug used in treatment of the central nervous system diseases.

EFFECT: valuable medicinal properties of compounds and pharmaceutical composition, improved method of synthesis.

26 cl, 2 tbl, 25 ex

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RU 2 320 656 C2

Authors

Gmajner Peter

Khjubner Kharal'D

Shlotter Karin

Dates

2008-03-27—Published

2003-07-02—Filed