FIELD: genetic engineering, virology, medicine.
SUBSTANCE: invention relates to method for production of modified Vaccinia virus Ankara (MVA). Claimed method includes contamination of mammalian continuous cell line with Vaccinia virus Ankara (MVA) of wild type, followed by viruses cultivation and collection. Further fresh cells of the same cell line are infected with newly formed viruses. Abovementioned steps optionally are repeated. Also disclosed are strains of modified Vaccinia virus Ankara (MVA) and utilization thereof. Said strains are capable to growth in continuous cell lines.
EFFECT: strains having decreased virulence in relates to mammalians.
20 cl, 5 tbl
| Title |
Year |
Author |
Number |
| MODIFIED VARIANT OF ANKARA VACCINA VIRUS |
2001 |
- Chaplin Pol
- Khauli Pol
- Majzinger Kristine
|
RU2290438C2 |
| RECOMBINANT MODIFIED SMALLPOX VIRUS, ITS USAGE (VERSIONS) AND CELL LINE INFECTED BY VIRUS (VERSIONS) |
1996 |
- Zutter Gerd
- Ol'Mann Marion
- Ehrfle Fol'Ker
|
RU2198217C2 |
| VIRAL VECTOR MANUFACTURE |
2014 |
|
RU2658487C2 |
| USING MVA (MODIFIED VACCINIA ANKARA) FOR TREATING PROSTATE CANCER |
2008 |
- Del'Kehr Alen
- Laus Rajner
- Mehndl Stefani
- Rauntri Rajan Blehr
- Legrand Fatema
|
RU2499606C2 |
| PARAPOXVIRUS VECTOR CONTAINING RABIES VIRUS ANTIGEN |
2011 |
- Martehno Oliv'E Mishel'
- Riddi Nanda Kumar Damavarapu
|
RU2545694C2 |
| VIRAL VACCINES |
2017 |
|
RU2778312C2 |
| METHOD OF PRODUCING TARGET VIRUS OR TARGET PROTEINS DIFFERENT FROM ADENOVIRUS, EXPRESSION CELL AND HOST CELL AND PRODUCTION METHODS THEREOF, USE OF EXPRESSION CELL |
2006 |
- Zandig Fol'Ker
- Jordan Ingo
- Brundke Ehlizabet
|
RU2449015C2 |
| COMBINATION THERAPY FOR TREATING CANCER WITH POXVIRUS EXPRESSING TUMOUR ANTIGEN AND ANTAGONIST AND/OR AGONIST OF IMMUNE CHECKPOINT INHIBITOR |
2014 |
- Rauntri, Rajan
- Foj, Syuzan
- Mendl, Stefani
- Delker, Alen
|
RU2714142C2 |
| RECOMBINANT STAIN OF VACΔ6 VACCINIA VIRUS WITH BROKEN GENES OF VIRALENCE C3L, N1L, J2R, A35R, A56R, B8R FOR THE PRODUCTION OF LIVE CULTURAL ATTENUATED VACCINE AGAINST NATURAL SMALLPOX AND OTHER ORTHOPOXVIRAL HUMAN INFECTIONS |
2016 |
- Yakubitskij Stanislav Nikolaevich
- Kolosova Irina Valerevna
- Maksyutov Rinat Amirovich
- Shchelkunov Sergej Nikolaevich
|
RU2621868C1 |
| IMMORTALISED CELL LINE OF BIRDS |
2008 |
- Ehrb Filipp
- Kapfer Marina
- Sil'Vestr Natali
|
RU2475536C2 |
