METHOD OF PRODUCING BENZO[b]THIOPHENE COMPOUND Russian patent published in 2016 - IPC C07D409/04 C07D409/14 

FIELD: chemistry.

SUBSTANCE: invention relates to a method of producing a compound of formula (4): (4) (2) (3) (1), wherein R¹ is a hydrogen atom or a protective group, or salt thereof, by reacting a compound of formula (2), in which X¹ is a leaving group, with a compound of formula (3), wherein R¹ is defined above, or a salt thereof, wherein said method involves reacting a compound of formula (2), with a compound of formula (3), or a salt thereof in presence of (a) palladium compound and tertiary phosphine, or (b) palladium carbene complex, in an inert solvent or in absence of solvent; where tertiary phosphine is at least one compound selected from a group comprising tri-tert-butylphosphine, 2-(di-tert-butylphosphino)-1,1′-biphenyl, 2-(di-tert-butylphosphino)-2′-methyl-1,1′-biphenyl, 2-(di-tert-butylphosphino)-1,1′-binaphthyl, 2-dicyclohexylphosphino-2′,6′-dimethoxy-1,1′-biphenyl, 2-dicyclohexylphosphino-2′,6′-di-iso-propoxy-1,1′-biphenyl, N-phenyl-2-(di-tert-butylphosphino)pyrrole and 1-phenyl-2-(di-tert-butylphosphino)-1H-indene. Invention also relates to methods of producing a compound of formula (1).

EFFECT: obtaining compounds of formula 4 with high output.

14 cl, 1 tbl, 16 ex