FIELD: medicine, hematology.
SUBSTANCE: the present innovation deals with isolating DNA out of lymphocytes of peripheral venous blood due to phenol-chloroform extraction, carrying out the procedure of genotyping polymorphism of promoter area of gene CYP1A1 in site - Ile 462 Val due to polymerase chain reaction of DNA synthesis and subsequent restriction. At detecting genotype Ile-Val one should predict high risk for the development of toxic medicinal hepatitis.
EFFECT: higher accuracy of prediction.
1 tbl
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