STONE OIL FROM STONE FRUITS, METHOD FOR EXTRACTION THE SAME, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF Russian patent published in 2006 - IPC A61K36/185 A61K36/889 A61K9/48 A61K9/10 A61P35/00 A61P37/00 A61P31/18 

FIELD: pharmaceutical industry.

SUBSTANCE: invention relates to stone oil, extracted from stones of date (Phoenix pubeccens), yellow wood, or walnut containing specific amounts of triglycerides, diglycerides, monoglycerides, sitosterols, and cycloalanosterol. In one embodiment method for extraction of stone oil includes pressing of stones or powered stones, extraction with organic solvent or selectively by using of liquid in above-critical state to produce crude oil; discoloration thereof with adsorbing discoloration agent; dissolution of discolored oil in light ligroin; addition of stoichiometric amount of NaOH under stirring; settlement and aliquation; washing of organic phase with warm water to produce emulsion; addition of acetone to emulsion under stirring; layer separation and producing of oily phase in upper layer; treatment of oily phase to absorb thereof subsequently with neutral aluminum oxide and kaolin; removing after filtration of organic solvent from filtrate in nitrogen atmosphere; oily phase washing with warm water; heating of oily phase in nitrogen atmosphere to dehydrate thereof; and adsorption with neutral aluminum oxide. In another embodiment method for extraction of stone oil includes pressing of stones or powered stones, extraction with organic solvent or selectively by using of liquid in above-critical state to produce crude oil; stirring and heating of crude oil; adding of phosphorus acid to provide full degumming; addition of NaOH or Na₂CO₃ solution to degummed oil at the same temperature to provide full caustic purification; mixture settlement and aliquation to produce purified oil; washing of purified oil with pure water; addition of adsorbent to washed oil or heating thereof in vacuum to remove water and produce transparent dehydrated oil; discoloration thereof with adsorbing discoloration agent under heating in vacuum and under stirring in nitrogen atmosphere and oil heating up to certain temperature; passing of pure water steam at certain temperature and holding for certain time followed by stopping of purified water steam passing and nitrogen passing under stirring to remove moisture from oil. Pharmaceutical compositions improving of immunological function, increasing serum protein content and tumor growth inhibiting, which contains therapeutically effective amount of stone oil and one or more pharmaceutically acceptable adjuvants also are disclosed.

EFFECT: stone oil effectively improving of immunological function, increasing serum protein content and tumor growth inhibiting.

14 cl, 5 tbl, 11 ex