SALTS OF BENZOTHIOPYRANONE COMPOUNDS, METHOD FOR PRODUCTION AND USE THEREOF Russian patent published in 2025 - IPC C07D335/04 A61K31/4535 A61P31/06 

FIELD: medicine; pharmaceutics.

SUBSTANCE: invention relates to a pharmaceutically acceptable salt and 2-(4-(cyclohexyl)methyl)piperazin-1-yl)-8-nitro-6-(trifluoromethyl)-4H-thiochromen-4-one represented by formula (I), where salt is selected from 2-(4-(cyclohexyl)methyl)piperazin-1-yl)-8-nitro-6-(trifluoromethyl)-4H-thiochromen-4-one 1maleate, 2-(4-(cyclohexyl)methyl)piperazine-1-yl)-8-nitro-6-(trifluoromethyl)-4H-thiochromen-4-one 3/2fumarate, 2-(4-(cyclohexyl)methyl)piperazin-1-yl)-8-nitro-6-(trifluoromethyl)-4H-thiochromen-4-one 1citrate and 2-(4-(cyclohexyl)methyl)piperazine-1-yl)-8-nitro-6-(trifluoromethyl)-4H-thiochromen-4-one 1L-malate. Invention relates to a method of producing a pharmaceutically acceptable salt according to the invention, which involves steps of reacting 2-(4-(cyclohexyl)methyl)piperazin-1-yl)-8-nitro-6-(trifluoromethyl)-4H-thiochromen-4-one with pharmaceutically conventional acid in a solvent, which is an alcohol, at room temperature or under conditions of boiling under backflow condenser for 2–8 hours to obtain a salt shown in formula (I) through a salt formation reaction. Invention also relates to a pharmaceutical composition for treating and/or preventing a microbial infectious disease caused by Mycobacterium tuberculosis, characterized by the fact that pharmaceutical composition contains an effective amount of a pharmaceutically acceptable salt according to the invention and one or more pharmaceutically acceptable carriers, excipients, diluents, adjuvants and media.

EFFECT: pharmaceutically acceptable salts of 2-(4-(cyclohexyl)methyl)piperazin-1-yl)-8-nitro-6-(trifluoromethyl)-4H-thiochromene-4-one for preparing a drug for treating and/or preventing a microbial infection diseases caused by Mycobacterium tuberculosis.

4 cl, 7 tbl, 10 ex