FIELD: organic chemistry, chemical technology, medicine, pharmacy.
SUBSTANCE: invention relates to inclusion complexes of butylphthalide that is a derivative of D,L-mixed or levorotatory isomer with cyclodextrin or cyclodextrine derivatives, and to a method for their synthesis. Method involves interaction of butylphthalide with cyclodextrin or cyclodextrin derivatives to form a complex compound but preferably with hydroxypropyl-β-cyclodextrin that results to increasing water-solubility of butylphthalide and allows preparing solid or liquid clinical medicinal formulations and improving the curative effect of butylphthalide. The complex wherein the molar ratio of butylphthalide to cyclodextrin or cyclodextrine derivatives in the range = 1:(1-10) can be used in preparing infusion solutions, injections, powders for injections, liquids for oral administration, syrups, tablets, granules, dispersed tablets and other formulations.
EFFECT: improved preparing method.
14 cl, 8 ex
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