LACTAM COMPOUNDS AND THEIR PHARMACEUTICAL USING Russian patent published in 2006 - IPC C07D487/04 C07D498/04 C07D513/04 A61K31/5517 A61K31/551 A61K31/55 A61P3/10 

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to novel lactam compounds of the formula (I) or their pharmaceutically acceptable salts wherein A means phenyl, thienyl, pyridyl, pyrimidinyl, pyrazinyl; R², R³ and R⁴ can be similar or different and mean independently of one another hydrogen atom (H), halogen atom, -OH, (C₁-C₆)-alkyl, (C₁-C₆)-alkoxy-group, -NH₂, -NO₂, -CF₃, phenyl that can comprise substitute(s), benzyloxy-group that can comprise substitute(s), pnehylvinyl, and one among R², R³ and R⁴ means -CF₃-O- and others mean H; B means phenyl that can comprises substitute(s), monocyclic aliphatic (C₃-C₈)-ring, dihydropyrane ring; -X- and -Y- xan be similar or different and they mean independently -O-, -NH-, -NR⁵-, -S-; Z means -CH₂-, -NH-; W means -NR¹-, -CR⁸R⁹- wherein R¹ means H; R⁸ and R⁹ are similar or different and mean H; wherein R⁵ represents a linear alkyl group that can comprise substitute(s), (C₁-C₈)-linear or branched alkoxycarbonyl group, acyl group chosen from formyl group, acyl group comprising (C₁-C₆)-alkyl, (C₁-C₆)-alkenyl or (C₁-C₆)-alkynyl group that can comprise substitute(s), carbamoyl group comprising (C₁-C₆)-alkyl group at nitrogen atom that can comprise substitutes, sulfonyl group comprising (C₁-C₆)-alkyl group at sulfur atom that can comprise substitute(s); each among a, b and c represents position of carbon atom under condition that: (i) substitute(s) is chosen from the group comprising halogen atom, -OH, (C₁-C₆)-alkyl, mercapto-group, (C₁-C₆)-alkoxy-group, -NO₂, -COOH, -CF₃, phenyl, -NH₂, (C₁-C₈)-linear or branched alkoxycarbonyl group, (C₁-C₈)-linear or branched acyl group, (C₁-C₈)-linear or branched acyloxy-group; (ii) when B represents benzene ring, each among -X- and -Y- represents -NH-, -Z- represents -CH₂- and -W- represents -NH- then R², R³ and R⁴ can not mean phenyl group, 4-bromophenyl group, 4-hydroxyphenyl group, 4-methoxyphenyl group, 2-hydroxyphenyl group, 3,4-dimethoxyphenyl group or 3-methoxy-4-hydroxyphenyl group. Compounds of the formula (I) show the enhanced capacity for transport of sugar and can be used in pharmaceutical compositions for prophylaxis and/or treatment of diabetes mellitus and diabetic nephropathy.

EFFECT: valuable medicinal properties of compounds and pharmaceutical compositions.

19 cl, 21 tbl, 54 ex