FIELD: organic chemistry, medicine, biochemistry, pharmacy.
SUBSTANCE: invention describes derivatives of imidazolidine-2,4-dione of the formula (I)
or its pharmaceutically acceptable salt wherein X is chosen from NR1; Y1 and Y2 represent oxygen atom (O); z is chosen from O or sulfur atom (S); A is chosen from a direct bond and (C1-C6)-alkyl; R1 is chosen from hydrogen atom (H) and (C1-C3)-alkyl; R2 is chosen from H, alkyl, cycloalkyl, aryl, heteroaryl, arylalkyl and heteroarylalkyl; R3 and R4 are chosen from H and (C1-C3)-alkyl; R2 can be substituted with one or more groups chosen from alkyl, halogen atom, hydroxy- and alkoxy-group; R2 and R3 can be joined to form a ring comprising up to 7 ring atoms; R5 represents bicyclic or tricyclic group comprising two or three ring structures wherein each comprises up to 6 ring atoms chosen independently from aryl or heteroaryl and wherein each ring structure can be substituted independently with one or more substitutes chosen independently from halogen atom, hydroxy-group, alkyl, alkoxy-group, halogenalkyl, halogenalkoxy-, amino-, N-alkylamino-, N,N-dialkylamino-, cyano-group and alkylsulfonyl, and each ring structure is joined with the next ring structure by a direct bond or through -O- or condensed with the next ring structure. Also, invention describes a pharmaceutical composition useful in inhibition of activity of metalloproteinases and using proposed compounds in preparing a drug. Derivatives of imidazolidine-2,4-dione are useful as inhibitors of metalloproteinases being especially as inhibitors of MMP12.
EFFECT: valuable medicinal and biochemical properties of compounds and pharmaceutical composition.
9 cl, 3 ex
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