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2 288 229

(13)

(51)

IPC

C07D405/12(2006-01-01)

(21) (22)

Application

2003132433/04, 2002-04-08

(24)

Start date

2002-04-08

(22)

Actual filing date

2002-04-08

(45)

Published

2006-11-27

(72)

Inventor

Bokel' Khajnts-GermannNojnfel'D ShteffenGanttsert LudvigKnirime Ral'FZimon Ehl'KeDefant Ral'FKhel'M UdoRojbol'D Khel'Mut

(73)

Holder

Merk Patent Gmbkh

METHOD FOR PREPARING 2-[5-(4-FLUOROPHENYL)-3-PYRIDYLMETHYLAMINOMETHYL]CHROMANE Russian patent published in 2006 - IPC C07D405/12

Abstract RU 2288229 C2

FIELD: organic chemistry, chemical technology.

SUBSTANCE: invention relates to a method for synthesis of 2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]chromane of the formula (I): and its salts. Method involves direct reaction of 5-(4-fluorophenyl)pyridine-3-carbaldehyde of the formula (II): with 2-aminomethylchromane or its salts under reductive conditions resulting to formation of compound of the formula (I). Synthesized compound of the formula (I) is converted to one of its salts by treatment with acid. Method provides simplifying process based on decreasing amount of by-side products formed.

EFFECT: improved method of synthesis.

8 cl, 2 dwg, 4 ex

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RU 2 288 229 C2

Authors

Bokel' Khajnts-Germann

Nojnfel'D Shteffen

Ganttsert Ludvig

Knirime Ral'F

Zimon Ehl'Ke

Defant Ral'F

Khel'M Udo

Rojbol'D Khel'Mut

Dates

2006-11-27—Published

2002-04-08—Filed