METHOD FOR PREDICTING GENETICALLY DETERMINISTIC HUMAN DISEASES Russian patent published in 2007 - IPC G01N33/53 G01N33/573 

Abstract RU 2293990 C1

FIELD: medicine.

SUBSTANCE: method involves determining patient acetylation phenotype and predicting disease from table data built in advance. The table has correlation coefficients between rapid and slow acetylation phenotype reoccurrence frequency in various countries, morbidity coefficients for predicting diseases under prognosis and mortality rates caused by the diseases in various age-specific human life intervals. The risks are predicted in the cases when patient has rapid acetylation phenotype, only if said coefficient values corresponding to patient phenotype and sex are positive, and in slow acetylation phenotype cases when the coefficients are negative. The risks are predicted in the cases when said correlation coefficient values have authenticity level equal to or less than 0.05. Prognosed diseases risks and lethal outcome risks caused by those diseases in given age intervals are determined from the values of the correlation coefficients in the range from -1 to +1. Clinical course severity is additionally estimated for particular patient in said age intervals depending on acetylation degree settled when determining patient phenotype. Acetylation degree is taken into consideration.

EFFECT: high accuracy of prognosis.

6 cl, 2 tbl

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RU 2 293 990 C1

Authors

Fursenko Sergej Aleksandrovich

Gjul'Azizova Karineh Sergeevna

Nikolaeva Irina Sergeevna

Radkevich Ljudmila Aleksandrovna

Dates

2007-02-20Published

2006-01-24Filed