PRODUCTION METHOD OF (E)-4-(INDOL-2-YL)PROP-2-EN-1-ONE DERIVATIVES Russian patent published in 2017 - IPC C07D209/12 

Abstract RU 2633999 C1

FIELD: chemistry.

SUBSTANCE: invention relates to the heterocyclic compounds synthesis - derivatives of (E)-4-(indol-2-yl)prop-2-en-1-one, which are of interest as the initial compounds for the pharmaceutical substances synthesis. The production method of (E)-4-(indol-2-yl)prop-2-en-1-one I derivatives involves in reaction of the available 2-(N-tosylamino) benzyl alcohols with 2-substituted furans with the reaction mixture further treatment with acetate palladium, para-benzoquinone and molecular iodine in the glacial acetic acid under heating.

Postal index.

EFFECT: increase of the yield.

2 tbl, 10 ex

Similar patents RU2633999C1

Title Year Author Number
METHOD PRODUCING 4-{1-[(4-METHYLPHENYL)SULPHONYL]-1H-INDOL-2-YL}BUT-3-EN-2-ONE DERIVATIVES 2012
  • Uchuskin Maksim Grigor'Evich
  • Lysenko Sergej Aleksandrovich
  • Molodtsova Natal'Ja Vladimirovna
  • Trushkov Igor' Viktorovich
  • Butin Aleksandr Valerianovich
RU2488581C1
METHOD FOR OBTAINING DERIVATIVES OF 2-(2-ACYLVINYL)INDOLES 2014
  • Merkushev Anton Andreevich
  • Makarov Anton Sergeevich
  • Uchuskin Maksim Grigor'Evich
  • Butin Aleksandr Valerianovich
RU2570421C1
METHOD OF PRODUCING 2-(BENZYL)FURAN DERIVATIVES 2014
  • Uchuskin Maksim Griror'Evich
  • Makarov Anton Sergeevich
  • Butin Aleksandr Valerianovich
  • Sorotskaja Ljudmila Nazarovna
RU2570420C1
METHOD FOR SYNTHESIS OF 4-(1H-INDOL-3-YL)-BUT-3-EN-2-ONE DERIVATIVES 2009
  • Butin Aleksandr Valerianovich
  • Pilipenko Arkadij Sergeevich
  • Uchuskin Maksim Grigor'Evich
RU2409564C1
METHOD OF OBTAINING DERIVATIVES FROM (E)-2-(2-ACYLVINYL)BENZOFURANE 2016
  • Merkushev Anton Andreevich
  • Uchuskin Maksim Grigorevich
  • Makarov Anton Sergeevich
  • Sorotskaya Lyudmila Nazarovna
  • Trushkov Igor Viktorovich
RU2633998C1
METHOD OF PRODUCING 4-(3,5-DIPHENYLFURAN-2-YL)BUTANONE-2 DERIVATIVES 2016
  • Makarov Anton Sergeevich
  • Fadeev Aleksandr Alekseevich
  • Uchuskin Maksim Grigorevich
  • Trushkov Igor Viktorovich
RU2634000C1
METHOD OF OBTAINING DERIVATIVES OF 2-ARYL(HETARYL)-1H-INDOLES 2010
  • Uchuskin Maksim Grigor'Evich
  • Pilipenko Arkadij Sergeevich
  • Molodtsova Natalija Vladimirovna
  • Butin Aleksandr Valerianovich
RU2439056C1
METHOD OF PRODUCING 2-(2-ACYLVINYL)INDOLES 2012
  • Serdjuk Ol'Ga Vladimirovna
  • Plieva Anastasija Tairovna
  • Uchuskin Maksim Grigor'Evich
  • Trushkov Igor' Viktorovich
  • Butin Aleksandr Valerianovich
  • Abaev Vladimir Tajmurazovich
RU2495027C1
METHOD FOR PREPARING 4-[1-(TOLYL-4-SULFONYL)-1H-INDOLYL-2]-BUT-3-ENE-2-ONE'S 2005
  • Smirnov Sergej Konstantinovich
  • Butin Aleksandr Valerianovich
RU2294325C2
METHOD OF PRODUCING BIS(5-ALKYL-2-FURYL)(2-AZIDOPHENYL)METHANE DERIVATIVES 2012
  • Serdjuk Ol'Ga Vladimirovna
  • Plieva Anastasija Tairovna
  • Abaev Vladimir Tajmurazovich
  • Uchuskin Maksim Grigor'Evich
  • Butin Aleksandr Valerianovich
RU2502735C1

RU 2 633 999 C1

Authors

Makarov Anton Sergeevich

Uchuskin Maksim Grigorevich

Zelina Elena Yurevna

Trushkov Igor Viktorovich

Dates

2017-10-23Published

2016-12-14Filed