FIELD: chemistry.
SUBSTANCE: invention relates to a method of producing 4-{1-[(4-methylphenyl)sulphonyl]-1H-indol-2-yl}but-3-en-2-one derivatives of general formula I: 
via temperature control of a mixture of readily available 2-(N-tosylamino)benzhydrol of formula:
,
where the values of R1-R3 are given above, and N-[(furan-2-yl)methyl]-4-methyl benzenesulphamide in acetic acid in the presence of catalytic amounts of hydrochloric acid at temperature of 40°C for 48 hours.
EFFECT: method enables to reduce resinification of the reaction mixture and increases output of end products.
2 tbl, 10 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR PREPARING 4-[1-(TOLYL-4-SULFONYL)-1H-INDOLYL-2]-BUT-3-ENE-2-ONE'S | 2005 |
|
RU2294325C2 |
| PRODUCTION METHOD OF (E)-4-(INDOL-2-YL)PROP-2-EN-1-ONE DERIVATIVES | 2016 |
|
RU2633999C1 |
| METHOD FOR OBTAINING DERIVATIVES OF 2-(2-ACYLVINYL)INDOLES | 2014 |
|
RU2570421C1 |
| METHOD OF OBTAINING DERIVATIVES OF 2-ARYL(HETARYL)-1H-INDOLES | 2010 |
|
RU2439056C1 |
| METHOD OF PRODUCING (E)-4-(6,7-DIMETHOXY-2-METHYL-3-QUINOLYL)-3-BUTEN-2-ONE DERIVATIVES | 2010 |
|
RU2425034C1 |
| METHOD OF PRODUCING 2-(2-ACYLVINYL)INDOLES | 2012 |
|
RU2495027C1 |
| METHOD OF PRODUCING BIS(5-ALKYL-2-FURYL)(2-AZIDOPHENYL)METHANE DERIVATIVES | 2012 |
|
RU2502735C1 |
| METHOD OF PRODUCING 2-(BENZYL)FURAN DERIVATIVES | 2014 |
|
RU2570420C1 |
| METHOD FOR SYNTHESIS OF 4-(1H-INDOL-3-YL)-BUT-3-EN-2-ONE DERIVATIVES | 2009 |
|
RU2409564C1 |
| METHOD OF OBTAINING DERIVATIVES FROM (E)-2-(2-ACYLVINYL)BENZOFURANE | 2016 |
|
RU2633998C1 |
