FIELD: organic chemistry, chemical technology.
SUBSTANCE: invention relates to a method for preparing biologically active compounds, in particular, resveratrol of the formula (I): from Siberian cedar bark as a vegetable raw. Method involves extraction of Siberian cedar bark firstly with petroleum ether, 3 times for 3 h, at temperature 70-80°C for separation of terpene compounds followed by extraction of stilbene compounds by successive extraction with methyl-tert.-butyl ester and ethanol under the same conditions. Stilbene compounds are purified by column chromatography on silica gel followed by deglycosylation of prepared sum of stilbene glycosides by using lithium thioethylate at temperature 150°C in argon flow and the following O-demethylation of prepared resveratrol monomethyl ester by effect with boron tribromide in argon flow. Invention provides using available raw and high yield of the end product.
EFFECT: improved preparing method.
5 ex
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Authors
Dates
2007-03-10—Published
2005-10-03—Filed