Show metadata Hide metadata

(19)

(11)

2 479 582

(13)

(51)

IPC

C07D307/40(2006-01-01)

A61K31/341(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2012115828/04, 2012-04-19

(24)

Start date

2012-04-19

(22)

Actual filing date

2012-04-19

(45)

Published

2013-04-20

(72)

Inventor

Shul'Ts Ehl'Vira EhduardovnaMironov Maksim Evgen'EvichPokrovskij Mikhail AndreevichSherman Ksenija MikhajlovnaPokrovskij Andrej GeorgievichTolstikov Genrikh Aleksandrovich

(73)

Holder

Federal'Noe Gosudarstvennoe Bjudzhetnoe Uchrezhdenie Nauki Novosibirskij Institut Organicheskoj Khimii Im. N.N. Vorozhtsova Sibirskogo Otdelenija Rossijskoj Akademii Nauk So Ran)Federal'Noe Gosudarstvennoe Bjudzhetnoe Obrazovatel'Noe Uchrezhdenie Vysshego Professional'Nogo Obrazovanija Natsional'Nyj Issledovatel'Skij Gosudarstvennyj Universitet"

LABDANE-TYPE 6-HYDROXYNAPHTHOQUINONES, HAVING CYTOTOXIC ACTIVITY ON HUMAN TUMOUR CELLS Russian patent published in 2013 - IPC C07D307/40 A61K31/341 A61P35/00

Abstract RU 2479582 C1

FIELD: chemistry.

SUBSTANCE: invention relates to novel labdane-type 6-hydroxynaphthoquinones of formula: where R¹=R²=H (Ia); R¹=Me, R²=H (1b); R¹=H, R²=CO₂Et (Ic), which are capable of inhibiting growth of human tumour cells. The most active substance - (lS,4aS,8aR)-methyl 5-{2-[2-(6-hydroxy-1,4-dioxo-1,4-dihydronaphthalen-8-yl)-furan-3-yl]ethyl}-1,4a,6-trimethyl-1,2,3,4,4a,7,8,8a-octahydronaphthalene-1-carboxylate (Ia) inhibits growth of tumour cells CEM-13, U-937 and MT-4 in concentrations of 3.4, 5.8 and 4.3 mcM, respectively. The compounds are obtained from lambertian acid contained in the sap and needles of Siberian cedar.

EFFECT: improved method.

1 cl, 4 ex, 1 tbl

Similar patents RU2479582C1

Title	Year	Author	Number
16-(1,2,4-OXADIAZOL-3-YL)-15,16-EPOXILABDANOIDS POSSESSING CYTOTOXIC ACTIVITY ON HUMAN TUMOUR CELLS	2011	Shul'Ts Ehl'Vira Ehduardovna Kharitonov Jurij Viktorovich Pokrovskij Mikhail Andreevich Pokrovskij Andrej Georgievich Tolstikov Genrikh Aleksandrovich	RU2473550C1
N,N'((ALKANDIYL)BIS[LABDA-7(9),13,14-TRIENE-4-CARBOXAMIDES] WITH ANTITUMOUR ACTIVITY	2017	Kharitonov Yurij Viktorovich Shults Elvira Eduardovna Sorokina Irina Vasilevna Sazonova Lyudmila Vyacheslavovna Tolstikova Tatyana Genrikhovna Pokrovskij Andrej Georgievich Pokrovskij Mikhail Andreevich	RU2654201C1
N-SUBSTITUTED (1S,4AR,5S)-METHYL-5-[2-(2'-OXO-2',5'-DIHYDRO1-H-PYRROL-3'-YL)ETHYL]-1,4A-DIMETHYL-6-METHYLENEDECAHYDRONAPHTHALENE-1-CARBOXYLATES HAVING ANTICONVULSANT ACTIVITY	2008	Shul'Ts Ehl'Vira Ehduardovna Chernov Sergej Viktorovich Tolstikova Tat'Jana Genrikhovna Dolgikh Margarita Petrovna Bolkunov Aleksej Viktorovich Tolstikov Genrikh Aleksandrovich	RU2385863C2
METHOD OF PRODUCING COREY LACTONE ENANTIOMERIC DERIVATIVES	2011	Loza Vladimir Valer'Evich Vostrikov Nikolaj Sergeevich Miftakhov Mansur Sagar'Jarovich	RU2501793C2
DERIVATIVE OF 1'-BROMO-2',3',4'-TRIMETOXYBENZO[5',6':4,5]-(AR, 1S)-1-ACETAMIDO-6,7-DIHYDROCYCLOHEPTA-[3,4-F]-1H-INDOLE AND ITS APPLICATION	2016	Shchegravina Ekaterina Sergeevna Fedorov Aleksej Yurevich Svirshchevskaya Elena Viktorovna	RU2630303C1
METHOD FOR PREPARING SUBSTITUTED O-ALKYLATED HEXAHYDRO-2H-CHROMENO[4,3-D]PYRIMIDINE-2,5(1H)-DIONES	2022	Makarova Elena Sergeevna Filimonov Sergej Ivanovich Kabanova Mariya Valerevna Chirkova Zhanna Vyacheslavovna Abramov Igor Gennadevich	RU2796532C1
1-ADAMANTYL-3-(((1R,4AS,10AR)-7-ISOPROPYL-1,4A-DIMETHYL-1,2,3,4,4A,9,10,10A-OCTAHYDROPHENANTHREN-1-YL)METHYL)UREA, WHICH EXHIBITS INHIBITING ACTION ON HUMAN TYROSYL-DNA-PHOSPHODIESTERASE 1 ENZYME AND INCREASES ACTIVITY OF TEMOZOLOMIDE AGAINST GLIOBLASTOMA CELLS	2019	Oleshko Olga Sergeevna Kovaleva Kseniya Sergeevna Yarovaya Olga Ivanovna Mamontova Evgeniya Mikhajlovna Zakharenko Aleksandra Leonidovna Zakharova Olga Dmitrievna Cheresiz Sergej Vladimirovich Pokrovskij Andrej Georgievich Lavrik Olga Ivanovna Salakhutdinov Nariman Faridovich	RU2697409C1
1,1'-(HEXANE-1,6-DIYL)BIS(3-(((1R,4AS,10AR)-7-ISOPROPYL-1,4A-DIMETHYL-1,2,3,4,4A,9,10,10A-OCTAHYDROPHENANTAREN-1-YL)METHYL)UREA, WHICH EXHIBITS INHIBITING ACTION ON HUMAN TYROSYL-DNA-PHOSPHODIESTERASE 1 ENZYME AND INCREASES TEMOZOLOMIDE ACTIVITY ON GLIOBLASTOMA CELLS	2019	Kovaleva Kseniya Sergeevna Oleshko Olga Sergeevna Yarovaya Olga Ivanovna Mamontova Evgeniya Mikhajlovna Zakharenko Aleksandra Leonidovna Zakharova Olga Dmitrievna Cheresiz Sergej Vladimirovich Pokrovskij Andrej Georgievich Lavrik Olga Ivanovna Salakhutdinov Nariman Faridovich	RU2724882C1
13-E-(2,4-DIOXO-1,2,3,4-TETRAHYDROPYRIMIDIN-5-YL) EUDESMANOLIDES HAVING ANTIULCER ACTIVITY	2013	Shul'Ts Ehl'Vira Ehduardovna Patrushev Sergej Sergeevich Dolgikh Margarita Petrovna Tolstikova Tat'Jana Genrikhovna	RU2536870C1
AGENT FOR INHIBITING HUMAN ENZYME TYROSYL-DNA-PHOSPHODIESTERASE 1 BASED ON PHENYLCOUMARINES, SENSITIZING TUMORS TO ANTITUMOUR AGENTS	2019	Khomenko Tatyana Mikhajlovna Zakharenko Aleksandra Leonidovna Cherepanova Arina Aleksandrovna Ilina Ekaterina Sergeevna Zakharova Olga Dmitrievna Kaledin Vasilij Ivanovich Nikolin Valerij Petrovich Popova Nelli Aleksandrovna Volcho Konstantin Petrovich Lavrik Olga Ivanovna Salakhutdinov Nariman Faridovich	RU2724878C1

RU 2 479 582 C1

Authors

Shul'Ts Ehl'Vira Ehduardovna

Mironov Maksim Evgen'Evich

Pokrovskij Mikhail Andreevich

Sherman Ksenija Mikhajlovna

Pokrovskij Andrej Georgievich

Tolstikov Genrikh Aleksandrovich

Dates

2013-04-20—Published

2012-04-19—Filed