NSAID PREPARATION CONTAINING GRANULATED COMPOSITION AND EXTRA-GRANULATED COMPOSITION Russian patent published in 2007 - IPC A61K31/192 A61K9/16 A61K9/20 A61P29/00 

FIELD: medicine, pharmacy.

SUBSTANCE: invention proposes a preparation containing granulates and extra-granulated compositions. Granulated composition comprises numbers of hardened granules form a melt and containing the constant phase of non-steroid anti-inflammatory drug (NSAID). NSAID is chosen from racemic naproxen, racemic flurbiprofen, racemic ibuprofen and racemic ketoprofen. Granules are prepared by the complete melting of NSAID. Extra-granulated composition comprises a water-insoluble absorbing agent. Absorbing agent represents at least one inorganic substance, stearic acid or its insoluble salt, starch substance, cellulose substance or their mixture, polytetrafluoroethylene powder. The preparation doesn't comprise silicon dioxide. The proposed preparation is used in pain treatment and/or inflammation, and/or fever. The preparation shows improved properties for tabletting, in particular, good fluidity and provides preparing small tablets. The preparation as a single dosed formulation releases high percent of NSAID for relatively short period.

EFFECT: improved and valuable pharmaceutical properties of preparation.

37 cl, 53 ex