GRANULES CONTAINING PARACETAMOL, NSAID AND SUGAR ALCOHOL PREPARED BY MELT EXTRUSION Russian patent published in 2010 - IPC A61K9/16 A61K47/26 A61K47/04 A61K31/167 A61K31/192 A61K9/20 A61J3/00 A61P29/00 

FIELD: medicine.

SUBSTANCE: pharmaceutical composition contains a granulated component including multiple hardened melt granules of sugar alcohol containing included salt of nonsteroidal anti-inflammatory drug (NSAID salt) and paracetamol. The mass ratio of NSAID salt to paracetamol is 1:5 to 3:1. The pharmaceutical composition is used for pain and/or inflammation and/or fever management in coughing, cold, influenza, migraine, headache, rheumatic pain, articular pain, muscular pain and/or neuralgia.

EFFECT: according to the invention, the pharmaceutical composition contains minimum of tableting excipients, has improved fluidity and does not tend to adhere to stamps of a tableting machine.

38 cl, 3 dwg, 4 tbl, 21 ex