METHOD FOR DIAGNOSING INFLAMMATORY SYSTEM RESPONSE SYNDROME CASES FROM PRINCIPLE SURVIVAL SYSTEMS DATA Russian patent published in 2007 - IPC A61B10/00 

FIELD: medicine.

SUBSTANCE: method involves determining system injury labels A, where A=0 corresponds to no potentially dangerous injury being recognized; A=1 to availability of marked alteration with injury markers generalization like incompatible group blood transfusion, heavy traumas with hemorrhage with more than 1 l of blood lost, or visceral organ injury, burns of 3-4th severity degree with more than 10% of body surface area, heavy poisonings, sharp pyoinflammatory diseases satisfying to 2-4 SIRS criteria, development of anaphylactic system response; A=2 corresponds to availability of injuries being classified as critical conditions risk factor; intensity inflammatory system response manifestations B, where В=1 corresponds to availability of D-dimers in concentration greater than 3 mcg/ml or fibrin-monomer complexes or > 20 mcg/ml; availability of early stage organ microcirculation injury labels C, where C=1 corresponds to myoglobin level greater than 60 ng/ml with no signs of marked muscle tissue injury or greater than 800 ng/ml without injury conditions, or troponin level I- 0.2-1.0 ng/ml or greater than 1 ml when excluding primary myocardial infarction. Organ dysfunction is estimated in SOFA scale. Critical condition is evaluated as D where D=1 corresponds to 2-5 points of SOFA scale; D=2 corresponds to critical condition statement in the following cases. 1) 6-24 SOFA points, 2) 2-5 SOFA points with clinical multiple organ failure/dysfunction symptoms being available, 3) shock or decompensated disseminated intravascular coagulation syndrome phase availability. Emergency state development risk factors are determined, where F=1 shows to additional risk factors availability like age >60 years, immune deficiency states, diabetes mellitus, chronic cardiac or pulmonary insufficiency availability in anamnesis. A=1 and B=1 being found to take place, inflammatory system response syndrome is diagnosed. The case of A=1 and B=1 (with C=1 or D=1 and F=1 as well), or A=2, emergency state development risk caused by inflammatory system response syndrome is to be predicted. D=2 and/or A=2 being the case, emergency state is diagnosed.

EFFECT: high accuracy in estimating inflammatory system response syndrome development risk.

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