FIELD: biotechnology, biochemistry, enzymes.
SUBSTANCE: invention relates to crystalline structures of phosphodiesterase 5 (PDE 5) and complexes "PDE 5/ligand PDE 5", and their using for identification of PDE 5 ligands including compounds representing inhibitors of PDE 5. Also, invention relates to methods for identifying indicated compound inhibiting activity of PDE 5. The claimed invention provides preparing a novel crystal of enzyme.
EFFECT: valuable properties of crystalline enzyme.
24 cl, 5 dwg, 3 tbl, 15 ex
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