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(19)

(11)

2 607 080

(13)

(51)

IPC

C07D209/54(2006-01-01)

C07D401/06(2006-01-01)

C07D401/12(2006-01-01)

C07D403/12(2006-01-01)

C07D405/04(2006-01-01)

C07D405/12(2006-01-01)

C07D409/12(2006-01-01)

C07D413/12(2006-01-01)

A61K31/403(2006-01-01)

A61P3/00(2006-01-01)

(21) (22)

Application

2012119706, 2010-10-12

(24)

Start date

2010-10-12

(22)

Actual filing date

2010-10-12

(45)

Published

2017-01-10

(72)

Inventor

Zhan AkkermannShtefan BruggerOrilya KonteDaniel KhuntsikerVerner NajdkhartMattias NettekovenTanya Shults-GashStenli Vertkhajmer

(73)

Holder

F. Hoffmann-La Roche Ag

SPIRO-CONDENSED CYCLOHEXANE DERIVATIVES AS INHIBITORS OF HSL, EFFECTIVE FOR DIABETES TREATMENT Russian patent published in 2017 - IPC C07D209/54 C07D401/06 C07D401/12 C07D403/12 C07D405/04 C07D405/12 C07D409/12 C07D413/12 A61K31/403 A61P3/00

Abstract RU 2607080 C2

FIELD: pharmaceutics.

SUBSTANCE: present invention relates to novel compounds of formula (I), as well as to their pharmaceutically acceptable salts possessing activity of HSL inhibitors, to pharmaceutical composition, method of inhibiting of enzyme HSL lipase, as well as to use of disclosed compounds for preparing a drug. Values R¹, R², R³, C^a and C^b are given in the claim.

EFFECT: invention discloses spiro-condensed cyclohexane derivatives as inhibitors of HSL, effective for diabetes treatment.

24 cl, 377 ex

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RU 2 607 080 C2

Authors

Zhan Akkermann

Shtefan Brugger

Orilya Konte

Daniel Khuntsiker

Verner Najdkhart

Mattias Nettekoven

Tanya Shults-Gash

Stenli Vertkhajmer

Dates

2017-01-10—Published

2010-10-12—Filed