FIELD: chemistry.
SUBSTANCE: invention relates to an improved method of producing protected (R)-3-amino-4-(2,4,5-trifluorophenyl)butanoic acid of formula 2, as shown on dwg 1, and a dipeptidyl peptidase-IV inhibitor intermediate compound. The method involves: (step a) obtaining a compound of formula 6 by opening the epoxide ring in compound 5, using Grignard reagent; (step b) obtaining a compound of formula 7 by reacting the compound of formula 6 with sodium azide; (step c) obtaining a compound of formula 8 by reacting the compound of formula 7 with triphenyl phosphine and adding an amine protective group (PG); (step d) obtaining a compound of formula 9 by opening the aziridine ring in compound 8 using a cyanogens-based reagent; and (step e) obtaining a compound of formula 2 by hydrolysis of the compound of formula 9 using a base; [Reaction scheme 1] 
, where X denotes a halogen and PG denotes a protective group. Novel intermediate compounds are described.
EFFECT: improved method.
12 cl, 3 dwg, 4 ex
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