IMPROVED METHOD OF PRODUCING DIPEPTIDYL PEPTIDASE-IV INHIBITOR AND INTERMEDIATE COMPOUND Russian patent published in 2013 - IPC C07C213/00 C07C219/18 C07D241/08 C07C219/06 C07C229/34

Abstract RU 2498976 C9

FIELD: chemistry.

SUBSTANCE: method is demonstrated on the scheme Method includes the following steps: (step 1) preparing a compound represented by chemical formula 4 by bonding a compound represented by chemical formula 2 and a compound represented by chemical formula 3 with peptide bond by reacting them using isobutyl chloroformate and a base in the presence of a reaction solvent; and (step 2) preparing a compound represented by chemical formula 1 by removing an amine protective group from the compound represented by chemical formula 4 obtained at step 1. On the reaction scheme, PG is a protective group; X is OR¹, where R¹ is a lower C₁-C₅alkyl; HY is a free acid. The invention also relates to a method of producing a compound represented by chemical formula 2, and an intermediate compound used to produce a compound represented by chemical formula 3.

EFFECT: method increases output of dipeptidyl peptidase-IV inhibitor, represented by chemical formula 1.

12 cl, 8 ex

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RU 2 498 976 C9

Authors

Kwak Woo Young

Kim Heung Jae

Min Jong Pil

Yoon Tae Hyun

Shim Hyun Joo

Yoo Moohi

Dates

2013-11-20—Published

2010-03-30—Filed