FIELD: medicine.
SUBSTANCE: group of inventions relates to medicine and concerns a medicinal agent for treating cancer, comprising a Toll-like receptor agonist and a LAG-3 protein, a variant or derivative thereof, where the Toll-like receptor agonist is Toll-like receptor 3 agonist, and the LAG-3 protein, a variant or derivative thereof is a fusion protein of LAG-3 and IgG protein. Group of inventions also relates to using a combination comprising a Toll-like receptor agonist and a LAG-3 protein, a variant or derivative thereof, for inducing a specific immune response against a cancer cell.
EFFECT: group of inventions provides reducing the tumour size and increasing the survival rate.
11 cl, 1 ex, 26 dwg
Title |
Year |
Author |
Number |
MEDICINAL PRODUCT |
2017 |
- Miyakawa, Tomoya
- Doi, Shun
- Tamada, Koji
|
RU2759728C2 |
COMPOSITIONS CAUSING SPECIFIC RESPONSE OF CYTOTOXIC T-LYMPHOCYTES, INCLUDING LYMPH-ABLATIVE COMPOUND AND MOLECULE WHICH CONTAINS ANTIGEN SEQUENCES AND IS TARGETED AT SPECIALISED ANTIGEN-PRESENTING CELLS |
2007 |
- Previll' Ksav'E
- Timmerman Benedikt
|
RU2448729C2 |
ANTI-CANCER VACCINE PREPARATION CONTAINING PEPTIDE WT1 IN THE FORM OF A TRANSDERMAL INTRODUCTION TAPE |
2014 |
- Maeda Josiki
- Okubo Katsuyuki
- Asari Dajsuke
- Okadzaki Arimiti
- Sisido Takuya
- Khori Mitsukhiko
- Sugiyama Kharuo
|
RU2697443C2 |
ANTICANCER VACCINE COMPOSITION CONTAINING WT1 PEPTIDE FOR TRANSDERMAL ADMINISTRATION |
2014 |
- Okubo Katsuyuki
- Maeda Josiki
- Okadzaki Arimiti
- Asari Dajsuke
- Sisido Takuya
- Khori Mitsukhiko
- Sugiyama Kharuo
|
RU2687144C2 |
COMBINATION OF AN IMMUNE CHECKPOINT MODULATOR AND A COMPLEX CONTAINING A CELL-PENETRATING PEPTIDE, A CARGO MOLECULE, AND A TLR PEPTIDE AGONIST, FOR APPLICATION IN MEDICINE |
2017 |
- Derouazi Madiha
- Belnoue Elodie
|
RU2769314C1 |
IMMUNOSTIMULATING COMBINATION FOR PREVENTION AND TREATMENT OF HEPATITIS C |
2006 |
- Sabaleta-Aspiros Aintsane
- Borras-Kuehsta Fransisko
- Prieto-Val'Tuehn'Ja Khesus
- Sarobe-Ugarrisa Pablo
- Lasarte-Sagastibel'Sa Khuan-Khose
|
RU2431499C2 |
COMBINATION OF IMMUNE CHECKPOINT MODULATOR AND COMPLEX CONTAINING CELL-PENETRATING PEPTIDE, CARGO MOLECULE, AND TLR PEPTIDE AGONIST FOR MEDICAL USE |
2017 |
- Deruazi Madikha
- Belnu Elodi
|
RU2748378C2 |
TUMOUR-REJECTING GLYPICAN-3 (GPC3)-DERIVATIVE ANTIGENIC PEPTIDES USED FOR HLA-A2-POSITIVE PATIENTS, AND PHARMACEUTICAL PRODUCT CONTAINING SAID PEPTIDES |
2006 |
- Nisimura Jasukharu
- Nakatsura Tetsuja
- Komori Khirojuki
|
RU2395519C2 |
DETERMINATION OF DOSE FOR IMMUNOTHERAPEUTIC AGENTS |
2017 |
- Strobl, Stefan Josef Christof Friedrich
- Roesemann, Roman Peter
- Sahin, Ugur
- Jahndel, Veronika
- Schwarck-Kokarakis, Doreen
- Husemann, Yves
- Dorer, Kathrin
- Jabulowsky, Robert
|
RU2771717C2 |
MUTANT POLYPEPTIDES SUAA AND POLYPEPTIDE DERIVATIVES SUITABLE FOR DELIVERY OF IMMUNOGENIC MOLECULES IN CELL |
2010 |
- Sebo Peter
- Ositskova Adriana
- Masin Irzhi
- Fajol Katrin
- Krusek Yan
- Basler Marek
- Leklerk Klod
- Ositska Radim
|
RU2585216C2 |