METHOD FOR ANALYSIS OF GENETIC POLYMORPHYSM, DEFINING PREDISPOSITION TO TUMOR DISEASES AND INDIVIDUAL SENSITIVITY TO PHARMACEUTICAL AGENTS BY USING OLYGONUCLEOTIDE BIOLOGICAL MICROARRAY (BIOARRAY) Russian patent published in 2007 - IPC C12N15/11 G01N33/48 C12Q1/68 

Abstract RU 2303634 C2

FIELD: molecular biology, clinical genetic, medicine.

SUBSTANCE: genetic polymorphysm is analyzed by amplification of polymorph gene fragments by two-step PCR and hybridization of obtained products on bioarray followed by registration and interpretation of obtained data. Specific primer kit is used for amplification of polymorph gene fragments. As bioarray in hybridization step substrate with set of specific oligonucleoide immobilized thereon is used.

EFFECT: method for detection of functional polymorph locus.

12 cl, 4 ex, 2 tbl, 14 dwg

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RU 2 303 634 C2

Authors

Zasedatelev Aleksandr Sergeevich

Nasedkina Tat'Jana Vasil'Evna

Glotov Andrej Sergeevich

Dates

2007-07-27Published

2005-10-11Filed