FIELD: organic chemistry.
SUBSTANCE: invention relates to novel individual compounds of series 2,5a-methano[1,4]diazepino[1,7-a]-quinoxaline-5-carboxylates, namely, to isopropyl-12-aroyl-2-hydroxy-1,6-dioxo-4-(3-pyridinyl)-7-phenyl-1,3,6,7-tetrahydro-2,5a-methano[1,4]diazepino[1,7-a]-quinoxaline-5-carboxylates of the formula (1) 
wherein Ar means phenyl or p-methoxyphenyl, and to a method for their synthesis. Method for synthesis of compound of the formula (1) involves interaction of 3-aroyl-5-phenylpyrrolo[1,2-a]-quinoxaline-1,2,4(5H)-triones with isopropyl-3-amino-3-(3-pyridinyl)-2-propenoate in an inert aprotonic solvent medium and the following isolation of end substances. The proposed method provides synthesis of novel compounds of the formula (1) possessing antibacterial effect with high yield and selectivity.
EFFECT: improved method of synthesis.
4 cl, 1 tbl, 3 ex
| Title |
Year |
Author |
Number |
| METHOD OF OBTAINING 1,2-DIHYDRO-3H-PYRIMIDO[1,6-A]QUINOXALINE-3,5(6H)-DIONES |
2018 |
- Maslivets Andrej Nikolaevich
- Kasatkina Svetlana Olegovna
- Stepanova Ekaterina Evgenevna
- Makhmudov Ramiz Ragibovich
|
RU2676682C1 |
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2008 |
- Racheva Nadezhda L'Vovna
- Maslivets Andrej Nikolaevich
- Aleksandrova Galina Arsent'Evna
|
RU2383550C1 |
| METHOD FOR PRODUCING (R*)-3-AROYL-2-HYDROXY-2-((S*)-2-OXOCYCLOALKYL)PYRROLO[1,2-A]QUINOXALINE-1,4(2H,5H)-DIONES |
2018 |
- Maslivets Andrej Nikolaevich
- Kasatkina Svetlana Olegovna
- Stepanova Ekaterina Evgenevna
- Balandina Svetlana Yurevna
|
RU2665060C1 |
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2019 |
- Apushkin Danila Yurevich
- Andreev Aleksandr Igorevich
- Mashevskaya Irina Vladimirovna
- Prikhodko Yaroslav Igorevich
|
RU2729185C1 |
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2021 |
- Mashevskaya Irina Vladimirovna
- Balandina Svetlana Yurevna
- Topanov Pavel Andreevich
|
RU2763732C1 |
| 20-AROYL-12-HYDROXY-17,17-DIMETHYL-3-PHENYL-3,10,13- TRIAZAPENTACYCLO-[10.7.1.0.0.0]-E ICOSA-4,6,8,14(19)-TETRAENE-2,11,15-TRIONES AND METHOD FOR THEIR PREPARING |
2004 |
- Mashevskaja I.V.
- Duvalov A.V.
- Bozdyreva K.S.
- Klinchina M.L.
- Dyrenkov R.O.
- Maslivets A.N.
|
RU2257386C1 |
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2019 |
- Tretyakov Nikita Alekseevich
- Maslivets Andrej Nikolaevich
- Makhmudov Ramiz Ragibovich
- Maslivets Anna Andreevna
|
RU2707196C1 |
| METHOD OF PRODUCING 3-AROYL-3A-(3,4-DIHYDRO-2H-PYRAN-5-YL)-2-HYDROXYPYRROLO[1,2-A]QUINOXALINE-1,4 (3AH, 5H)-DIONES |
2015 |
- Maslivets Andrej Nikolaevich
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- Stepanova Ekaterina Evgenevna
|
RU2581268C1 |
| 2A-ALKOXYCARBONYL-5-PHENYL-1H-SPIRO[CYCLOPROPA[2,3]PYRROLO[1,2-A]QUINOXALINE-3,3'-INDOLINE]-1,2,2',4(2AH,5H)-TETRAONS |
2023 |
- Mashevskaia Irina Vladimirovna
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|
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| 1-AROYLOXY-4-HYDROXY-3-OXO-1,2,3,4,4a,5,6,7,8,8a-DECAHYDROQUINOXALIN-2-SPIRO(1-o-HYDROXYPHENYL-4,5-DIOXO-2,3,4,5-TETRAHYDROPYRROLES) AND METHOD FOR THEIR PREPARING |
2007 |
- Mashevskaja Irina Vladimirovna
- Maslivets Andrej Nikolaevich
- Tikhonov Aleksej Jakovlevich
- Mazhukin Dmitrij Gennad'Evich
|
RU2320660C1 |
