FIELD: chemistry.
SUBSTANCE: invention relates to organic chemistry, namely to a method for producing compounds (R*)-3-aroyl-2-hydroxy-2-((S*)-2-oxocycloalkyl)pyrrolo[1,2-a]quinoxaline-1,4(2H, 5H)-dione (IIIa-c), where R=Ph, Ar=C6H4Cl-4, n=1 (a); R=H, Ar=C6H4Cl-4, n=1 (b); R=Ph, Ar=Ph, n=1 (c), by reacting 3-aroylpyrrolo[1,2-a]quinoxaline-1,2,4(5H)-trions(Ia-c) and cycloalkanes (II) at boiling point for 3–10 hours in inert aprotic solvents followed by isolation of target products.
.
EFFECT: developed is a simple method for the synthesis of (R*)-3-aroyl-2-hydroxy-2-((S*)-2-oxocycloalkyl)pyrrolo[1,2-a]quinoxaline-1,4(2H,5H)-diones IIIa-c), which can be used as starting products for the synthesis of new heterocyclic systems and in pharmacology.
1 cl, 1 tbl, 3 ex
| Title |
Year |
Author |
Number |
| 3-AROYL-2-HYDROXY-2-(2-OXOCYCLOALKYL)PYRROLO[2,1-C][1,4]BENZOXAZINE-1,4(2H)-DIONES HAVING ANALGESIC ACTIVITY AND METHODS FOR PRODUCTION THEREOF |
2014 |
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- Stepanova Ekaterina Evgen'Evna
- Makhmudov Ramiz Ragibovich
|
RU2564440C1 |
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2016 |
- Stepanova Ekaterina Evgenevna
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|
RU2631432C1 |
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2015 |
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|
RU2581268C1 |
| 3-(4-CHLOROBENZOYL)-2-HYDROXY-3a-(2-HYDROXY-4,4-DIMETHYL-6-OXOCYCLOHEX-1-en-1-yl)PYRROLO[1,2-a]QUINOXALIN-1,4 (3aH,5H)-DIONE WITH ANTIMICROBIAL ACTIVITY AND METHOD FOR ITS PRODUCTION |
2022 |
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|
RU2783264C1 |
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2018 |
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|
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2021 |
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2014 |
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RU2569899C1 |
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2016 |
- Stepanova Ekaterina Evgenevna
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- Kobelev Aleksandr Ivanovich
- Balandina Svetlana Yurevna
|
RU2627276C1 |
| METHOD OF PRODUCING 2-AMINO-9-AROYL-8-HYDROXY-6-(2-HYDROXYPHENYL)-1-THIA-3,6-DIAZASPIRO[4.4]NONA-2,8-DIENE-4,7-DIONE |
2019 |
- Maslivets Andrej Nikolaevich
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- Stepanova Ekaterina Evgenevna
- Balandina Svetlana Yurevna
|
RU2707195C1 |
| METHOD FOR THE PREPARATION OF 3-ARYL-N-BENZYL-2-HYDROXY-1-OXOBENZO[d]PYRROLO[2,1-b]THIAZOLE-3a(1H)-CARBOXAMIDES |
2021 |
- Maslivets Andrej Nikolaevich
- Khramtsova Ekaterina Evgenevna
- Lystsova Ekaterina Aleksandrovna
|
RU2764906C1 |
