FIELD: chemistry.
SUBSTANCE: invention relates to a new method for producing new 1,2-dihydro-3H-pyrimido[1,6-a]quinoxaline-3,5(6H)-diones of formula IIIa-c. Method consists in the fact that a finely powdered mixture of 3-aroyl-5-phenylpyrrolo[1,2-a]quinoxaline-1,2,4(5H)-trions with Schiff bases is heated to 190–200 °C (until the termination of the release of CO), followed by the selection of the target products. Reaction is carried out according to the following scheme:
.
In formulas Ia,b, IIa,b and IIIa-c substituents Ar, R1, R2 have the following meanings (I): Ar = Ph (a), C6H4OMe-4 (b); (II): R1 = Bn, R2 = C6H4Br-4 (a); R1 = R2 = Ph (b); (III): Ar = Ph, R1 = Bn, R2 = C6H4Br-4 (a); Ar = C6H4OMe-4, R1 = R2 = Ph (b); Ar = C6H4OMe-4, R1 = Bn, R2 = C6H4Br-4 (c).
EFFECT: compounds possess antihypoxic activity and can be used to obtain antihypoxic drugs of metabolic action.
1 cl, 2 tbl, 4 ex
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