15-AROYL-2-HYDROXY-5,5-DIMETHYL-2,3,5,6-TETRAHYDRO-1H-2,7B-METHANOBENZO[5,6][1,4]DIAZEPINO[1,7-A]QUINOXALINE-1,7,8(4H, 9H)TRIONS, HAVING ANTI-INFLAMMATORY ACTIVITY Russian patent published in 2020 - IPC C07D487/08 A61P29/00 

Abstract RU 2729185 C1

FIELD: chemistry.

SUBSTANCE: invention relates to 15-aroyl-2-hydroxy-5,5-dimethyl-2,3,5,6-tetrahydro-1H-2,7b-methanobenzo[5,6][1,4]diazepino[1,7-a]quinoxaline-1,7,8(4H, 9H) to trions of general formula given below, where Ar=4-ClC6H4, R=H (Ia); Ar=C6H5, R=CH2C6H5 (Ib); Ar=C6H5, R=2,4-diFC6H4 (Ic).

EFFECT: compounds Ia-c have anti-inflammatory activity.

1 cl, 2 tbl, 4 ex

Similar patents RU2729185C1

Title Year Author Number
20-AROYL-12-HYDROXY-17,17-DIMETHYL-3-PHENYL-3,10,13- TRIAZAPENTACYCLO-[10.7.1.0.0.0]-E ICOSA-4,6,8,14(19)-TETRAENE-2,11,15-TRIONES AND METHOD FOR THEIR PREPARING 2004
  • Mashevskaja I.V.
  • Duvalov A.V.
  • Bozdyreva K.S.
  • Klinchina M.L.
  • Dyrenkov R.O.
  • Maslivets A.N.
RU2257386C1
ISOPROPYL-12-AROYL-2-HYDROXY-1,6-DIOXO-4-(3-PYRIDINYL)-7-PHENYL-1,3,6,7-TETRAHYDRO-2,5α-METHANO[1,4]DIAZEPINO[1,7α]-QUINOXALINE-5-CARBOXYLATES AND METHOD FOR THEIR PREPARING 2006
  • Bozdyreva Ksenija Sergeevna
  • Maslivets Andrej Nikolaevich
  • Aleksandrova Galina Arsent'Evna
RU2304581C1
3-AROYL-4-HYDROXY-1-(2-HYDROXYPHENYL)-5',5'-DIMETHYLDISPIRO[2,5-DIHYDRO-1H-AZOL-2,2'-(2',5',6',7-TETRAHYDRO-3'H-AZOLO[1,2-a]AZOL) 7',1"-(1",4"-DIHYDRONAPHTHALENE)]-3',4",5-TRIONES AND METHOD FOR PREPARING THEM 2011
  • Konovalova Valerija Vladislavovna
  • Maslivets Andrej Nikolaevich
  • Shkljaev Jurij Vladimirovich
  • Makhmudov Ramiz Ragibovich
RU2485123C1
APPLICATION OF 2-[(R-BENZYLIDENE)HYDRAZONO]-8-HYDROXY-6-(2-HYDROXYPHENYL)-9-AROYL-1-THIA-3,6-DIAZASPIRO[4.4]NONA-8-EN-4,7-DIONES AS AGENTS WITH ANTI-INFLAMMATORY ACTIVITY 2022
  • Mashevskaia Irina Vladimirovna
  • Lukmanova Dzhamilia Nailevna
  • Apushkin Danila Iurevich
  • Utushkina Taisiia Andreevna
  • Iakushina Karolina Evgenevna
  • Andreev Aleksandr Igorevich
RU2783241C1
APPLICATION OF 3-AROYL-4-[2-(HYDROXYMETHYL)-PHENYLAMINO]-6',6'-DIMETHYL-1'-(3-FLUOROPHENYL)-6',7'-DIHYDRO-5H-SPIRO[FURAN-2, 3'-INDOLE]-2',4',5(1'H,5'H)-TRIONES AS AGENT WITH ANTIOXIDANT ACTIVITY 2023
  • Maslivets Anna Andreevna
  • Maslivets Andrei Nikolaevich
RU2806189C1
6,6-DIMETHYL-8-OXO-5,6,8,9-TETRAHYDROBENZO[F]-PYRROLO[2,1-ALPHA]ISOQUINOLINE-9-SPIRO-2-(3-AROYL-4-HYDROXY-1-O-HYDROXYPHENYL-5-OXO-2,5-DIHYDRO-1H-PYRROLES) AND 6,6-DIMETHYL-8-OXO-5,6,8,9-TETRAHYDROBENZO[F]PYRROLO[2,1-ALPHA]ISOQUINOLINE-9-SPIRO-2-(3-BENZOYL-4-HYDROXY-1-O-HYDROXYPHENYL-5-OXO-2,5-DIHYDRIO-1H-PYRROLE) ELICITING ANALGESIC ACTIVITY AND METHOD FOR THEIR PREPARING 2006
  • Anikina Lada Vladimirovna
  • Racheva Nadezhda L'Vovna
  • Maslivets Andrej Nikolaevich
  • Shkljaev Jurij Vladimirovich
RU2316557C1
METHOD OF PREPARING 3A-AROYL-2-ISOPROPYL-3-(ISOPROPYLIMINO)-3,3A-DIHYDROBENZO[d]PYRROLO[3',4':2,3]PYRROLO[2,1-b]THIAZOLE-1,4,5(2H)-TRIONES EXHIBITING ANTIOXIDANT ACTIVITY 2023
  • Maslivets Andrei Nikolaevich
  • Khramtsova Ekaterina Evgenevna
  • Lystsova Ekaterina Aleksandrovna
RU2810075C1
METHOD FOR OBTAINING 1'-ARYLHEXAGYRO-1N-SPIRO[PYRIMIDINE-5,2'-PYRROLYSINE]-2,4,6(1H, 3H, 5H)-TRIONES 2016
  • Tyrkov Aleksej Georgievich
  • Yurtaeva Ekaterina Alekseevna
RU2647240C1
METHOD FOR PRODUCING METHYL 3-AROYL-2-HYDROXY-1-OXOBENZO[D]PYRROLO[2,1-B]THIAZOLE-3A(1H)-CARBOXYLATES EXHIBITING ANTIOXIDANT ACTIVITY 2022
  • Maslivets Andrei Nikolaevich
  • Khramtsova Ekaterina Evgenevna
  • Lystsova Ekaterina Aleksandrovna
RU2785751C1
METHOD FOR THE PREPARATION OF 3-ARYL-N-BENZYL-2-HYDROXY-1-OXOBENZO[d]PYRROLO[2,1-b]THIAZOLE-3a(1H)-CARBOXAMIDES 2021
  • Maslivets Andrej Nikolaevich
  • Khramtsova Ekaterina Evgenevna
  • Lystsova Ekaterina Aleksandrovna
RU2764906C1

RU 2 729 185 C1

Authors

Apushkin Danila Yurevich

Andreev Aleksandr Igorevich

Mashevskaya Irina Vladimirovna

Prikhodko Yaroslav Igorevich

Dates

2020-08-05Published

2019-11-19Filed